腹腔鏡下保留腎單位手術(shù)對(duì)腎癌患者sCD44v6、sICAM-1、β-EP水平的影響

劉佳生

摘要：目的? 探討腹腔鏡下保留腎單位手術(shù)（RLNSS）對(duì)腎癌患者血清應(yīng)激指標(biāo)[β內(nèi)啡肽（β-EP）]及黏附分子水平[可溶性分化抗原44拼接變異體6（sCD44v6）、可溶性細(xì)胞間黏附分子-1（sICAM-1）]的影響。方法? 回顧性分析2017年2月～2019年10月我院收治的50例腎癌患者的臨床資料，依照不同手術(shù)方法將其分為對(duì)照組與試驗(yàn)組，各25例。對(duì)照組實(shí)施開放性腎癌根治術(shù)，試驗(yàn)組實(shí)施RLNSS手術(shù)治療，比較兩組血清應(yīng)激指標(biāo)（β-EP）及黏附分子水平（sCD44v6、sICAM-1）。結(jié)果? 術(shù)后第1天，試驗(yàn)組血清sCD44v6水平為（265.13±51.28）ng/ml、sICAM-1為（518.47±80.23）ng/ml，低于對(duì)照組的（280.65±59.77）ng/ml、（532.36±91.68）ng/ml，但差異無統(tǒng)計(jì)學(xué)意義（P>0.05）;術(shù)后第1天，試驗(yàn)組β-EP水平為（166.94±20.15）pg/ml，低于對(duì)照組的（189.44±26.33）pg/ml，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論? 腎癌患者實(shí)施RLNSS手術(shù)治療可減輕患者應(yīng)激反應(yīng)程度，對(duì)血清黏附分子水平影響較小。

關(guān)鍵詞：腎癌;腹腔鏡下保留腎單位手術(shù);應(yīng)激激素;黏附分子

中圖分類號(hào)：R737.11? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 文獻(xiàn)標(biāo)識(shí)碼：A? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? DOI：10.3969/j.issn.1006-1959.2020.14.035

文章編號(hào)：1006-1959（2020）14-0117-02

Effect of Laparoscopic Nephron-sparing Operation on the Levels of sCD44v6，sICAM-1

and β-EP in Patients with Renal Cell Carcinoma

LIU Jia-sheng

（Urology Department，Jiamusi Central Hospital，Jiamusi 154002，Heilongjiang，China）

Abstract：Objective? To explore the serum stress index [β endorphin （β-EP）] and the level of adhesion molecules [soluble differentiation antigen 44 splicing variant 6 （sCD44v6）， soluble cells] in laparoscopic nephron-sparing surgery （RLNSS） Inter-adhesion molecule-1 （sICAM-1）].Methods? The clinical data of 50 kidney cancer patients admitted to our hospital from February 2017 to October 2019 were retrospectively analyzed， and they were divided into a control group and a test group according to different surgical methods， 25 cases each.The control group underwent radical resection of renal cell carcinoma， and the experimental group underwent RNLSS surgery to compare the serum stress index （β-EP） and the level of adhesion molecules （sCD44v6， sICAM-1） between the two groups.Results? On the first postoperative day， the serum sCD44v6 level in the experimental group was （265.13±51.28） ng/ml and sICAM-1 was （518.47±80.23） ng/ml， which was lower than that in the control group （280.65±59.77） ng/ml and （532.36） ±91.68） ng/ml， but the difference was not statistically significant （P>0.05）; on the first postoperative day， the β-EP level of the test group was （166.94±20.15） pg/ml， which was lower than that of the control group （189.44±26.33） pg/ml， the difference was statistically significant （P<0.05）. Conclusion? The operation of RNLSS in patients with renal cell carcinoma can reduce the degree of stress response of patients and have little effect on the level of serum adhesion molecules.