厄貝沙坦聯合氨氯地平治療老年高血壓患者的效果評價

聶祥碧

[摘要] 目的 評價厄貝沙坦聯合氨氯地平治療老年高血壓患者效果。方法 研究對象為方便選取2015年2月—2018年2月老年高血壓患者例數200例，采用每日患者掛號的自然序列，單號為觀察組，雙號為對照組，分別實施厄貝沙坦聯合氨氯地平治療以及常規治療，將兩組患者的血壓水平、治療效果、腎小管功能指標以及尿微量蛋白指標進行對比。結果 治療后，觀察組收縮壓（125.52±1.34）mmHg、舒張壓（70.64±1.32）mmHg均低于對照組（t=54.458 3、57.286 2，P<0.05）;觀察組NAG（11.32±1.02）mg/L、Kim-1（469.32±1.54）ng/L，較對照組指標更有優勢（t=34.328 8、288.895 5，P<0.05）;觀察組治療總有效率95.00%高于對照組74.00%（χ2=16.835 3，P<0.05）;治療后，觀察組老年高血壓患者mAlb（14.09±5.61）mg/L、RBP（0.21±0.06）mg/L低于對照組（t=7.730 2，16.641 0，P<0.05）。結論 厄貝沙坦聯合氨氯地平治療老年高血壓患者的效果十分顯著，且安全性較高，對腎臟具有保護作用。

[關鍵詞] 厄貝沙坦;氨氯地平;老年高血壓;效果評價

[中圖分類號] R5? ? ? ? ? [文獻標識碼] A? ? ? ? ? [文章編號] 1674-0742（2019）09（a）-0097-03

[Abstract] Objective Convenient selected to evaluate the effect of irbesartan combined with amlodipine in the treatment of elderly hypertensive patients. Methods A total of 200 elderly patients with hypertension from February 2015 to February 2018 were enrolled. The natural sequence of daily patient registration was used. The single number was the observation group and the double number was the control group. The irbesartan combined with amlodipine and conventional treatment were performed. Blood pressure levels， treatment effects， renal tubular function indicators， and urine microprotein indicators were compared between the two groups. Results After treatment the systolic blood pressure （125.52±1.34） mmHg and diastolic blood pressure （70.64±1.32） mmHg in the observation group were lower than those in the control group （t=54.458 3， 57.286 2，P<0.05）; observation group NAG （11.32±1.02） mg/L， Kim-1 （469.32±1.54） ng/L， which was superior to the control group （t=34.328 8，288.895 5，P<0.05）; the total effective rate of the observation group was 95.00% higher than that of the control group 74.00% （χ2=16.835 3，P<0.05）; after treatment， mAlb （14.09±5.61） mg/L and RBP （0.21±0.06） mg/L in elderly hypertensive patients in the observation group were lower than the control group（t=7.730 2，16.604 1，P<0.05）. Conclusion The efficacy of irbesartan combined with amlodipine in the treatment of elderly hypertensive patients is very significant， and it is safe and has a protective effect on the kidney.

[Key words] Irbesartan; Amlodipine; Elderly hypertension; Effect evaluation

隨著社會人口老年化，老年高血壓發病率隨年齡增長而增高，老年人易受到器官功能儲備能力下降、多病共存、服藥種類較多等多種因素的影響，故此，在選擇藥物方面，應以不良反應小，藥物間相互不良反應小的藥物、方便、依從性好的藥物為主，能夠提高治療安全性，避免不良事件的發生[1-2]。因此，該院將收取時間在2015年2月—2018年2月200例老年高血壓患者作為研究對象，分別實施不同治療，探討治療效果，現報道如下。

1? 資料與方法