基于網絡藥理學研究肝經中藥與治療疾病的關系

王俊堯　陳建新　趙慧輝

摘要?目的：研究嘗試以網絡藥理學的方法對肝經中藥及治療疾病的關系進行研究，探索網絡藥理學研究中藥歸經的可能性。方法：選取從分子對接篩選出2015版《中華人民共和國藥典》中肝經中藥的活性靶點，并尋找中藥歸經與疾病的共同活性靶點，通頻次頻率的統計分析，探索中藥歸經與治療疾病的關系。結果：肝經中藥蛋白靶點在精神和行為障礙疾病、血液及造血器官疾病和涉及免疫機制的某些疾患，妊娠、分娩和產褥期相關疾病上有較高頻率的分布。結論：在網絡藥理學基礎上得到的肝經中藥與治療疾病的關系與中醫基礎理論中肝的生理功能有一定關聯。

關鍵詞?肝經;網絡藥理學;歸經;中藥;數據;關系;蛋白靶點

Relationship between Chinese Medicine of Liver Meridian and Treatment Based on Network Pharmacology

Wang Junyao，Chen Jianxin，Zhao Huihui

（Beijing university of Chinese medicine，Beijing 100029，China）

Abstract?Objective：The study of meridian tropism has great significance to the development of Chinese herbal medicine theory. In recent years network pharmacology had been widely used in the study of traditional Chinese medicine（TCM）. This study aims to explore the relationship between liver meridian and treatment based on network pharmacology for the possibility of meridian tropism theory adopting network pharmacology. Methods：Molecular docking was used to screen the active targets of Chinese medicine of liver meridian in Pharmacopoeia of the People′s Republic of China（2015）. Common active targets were searched between Chinese medicine of liver meridian and diseases. The frequency of Chinese medicine and protein with liver meridian in different disease would be analyzed to explore the relationship between tropism and indication. Results：The albumen targets of Chinese medicine of liver meridian has a high frequency in the diseases of mental and behavioural disorders，diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism，pregnancy，childbirth and the puerperium. Conclusion：The relationship between treatment and Chinese medicine of liver tropism based on network pharmacology is related to physiological function of liver.

Key Words?Liver meridian; Network pharmacology; Meridian tropism; Chinese medicine; Data; Relationship; Albumen target

中圖分類號：R285文獻標識碼：Adoi：10.3969/j.issn.1673-7202.2019.03.013

中藥歸經，是中藥藥性理論的重要組成部分，在指導中醫藥的臨床用藥中占有重要的地位。代表藥物作用與臟腑經絡的密切聯系。歸，指歸屬，代表了藥物作用的部位和走向。經，指人體的臟腑經絡。歸經理論，在藏象學說和經絡學說的基礎上，明確了藥物作用的定位和走向。研究藥物的歸經有利于進一步完善中藥藥性理論，指導臨床用藥，充分發揮藥物治療疾病的作用。既往學者已經通過大量的文獻和實驗研究對中藥歸經的化學成分類型分布[1-4]、部分疾病常用中藥的歸經[5-6]、部分醫家常用中藥的歸經[7-8]等方面進行了研究，取得了有意義的研究成果。但由于中藥成分的復雜性，現有的研究方法只能從某一角度來闡述和推測歸經的科學內涵，如根據極少數的幾味中藥，或某一中藥的幾個活性成分來探討中藥歸經的作用機制，并不能完全明確歸經的作用機制。……