R-CHOP方案治療B細胞非霍奇金淋巴瘤與CHOP方案對比的Meta分析

王建華

摘要：目的? 以Meta分析的方法來評價利妥昔單抗聯合CHOP方案治療B細胞性非霍奇金淋巴瘤的療效。方法? 計算機檢索維普數據庫、中國知網、萬方數據庫、pubmed數據庫等，檢索利妥昔單抗聯合化療治療B細胞性非霍奇金淋巴瘤的隨機對照試驗，并手工檢索相關會議記錄及紙質文獻，應用國際Cochrane協作網的系統評價方法對所得數據進行質量評分，進行資料提取后，采用RevMan5.3軟件進行Meta分析。結果? 共檢索到14個隨機對照試驗，共包括2433例患者，異質性檢驗P>0.1，基線具有可比性，選擇固定效應模型分析所得結果顯示R-CHOP方案化療組的完全緩解率高于單純CHOP化療組（RR=1.3，95%CI為1.3～1.41），差異有統計學意義（P<0.05）;R-CHOP方案總有效率高于CHOP組（RR=1.32，95%CI為1.22～1.42），差異有統計學意義（P<0.05）;其不良反應與對照組比較，差異無統計學意義（P>0.05）。結論? R-CHOP方案相對CHOP方案治療B細胞性非霍奇金淋巴瘤來說具有更高的完全緩解率和總有效率，進一步證明其治療效果需開展更多的隨機對照試驗。

關鍵詞：B細胞性非霍奇金淋巴瘤;利妥昔單抗;隨機對照試驗

中圖分類號：R551.2? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?文獻標識碼：A? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?DOI：10.3969/j.issn.1006-1959.2019.10.027

文章編號：1006-1959（2019）10-0081-04

Abstract：Objective? To evaluate the efficacy of rituximab combined with CHOP regimen in the treatment of B-cell non-Hodgkin's lymphoma by meta-analysis.Methods? A computer-based search of the Vip database， China Knowledge Network， Wanfang database， pubmed database， etc.， search for randomized controlled trials of rituximab combined with chemotherapy for B-cell non-Hodgkin's lymphoma， and manually retrieve relevant meeting minutes and paper In the literature， the systematic evaluation method of the international Cochrane Collaboration Network was used to score the quality of the data，after data extraction， Meta analysis was performed using RevMan5.3 software.Results? A total of 14 randomized controlled trials were included， including a total of 2，433 patients. The heterogeneity test was P>0.1， and the baseline was comparable. The results of the selected fixed-effects model showed that the complete response rate of the R-CHOP regimen was higher than that of CHOP alone. The chemotherapy group （RR=1.3， 95% CI 1.3～1.41）， the difference was statistically significant （P<0.05）; the total effective rate of R-CHOP regimen was higher than that of CHOP group （RR=1.32， 95% CI was 1.22～1.42），the difference was statistically significant（P<0.05）; the adverse reactions were not significantly different from the control group（P>0.05）.Conclusion? The R-CHOP regimen has a higher complete response rate and total effective rate than the CHOP regimen in the treatment of B-cell non-Hodgkin's lymphoma.It is further proved that the therapeutic effect requires more randomized controlled trials.