上海市男性同性戀HIV感染者中乙型肝炎、丙型肝炎病毒的合并感染情況橫斷面研究

洪亮 陶靜 張靜

摘要：目的? 探討男性同性戀HIV感染者中乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）的合并感染情況。方法? 選擇2016年1月～2018年1月在本區域內進行治療的男性同性戀HIV感染者157例，以橫斷面調查的方法進行研究，收集所有入組患者的性別、年齡、文化程度、感染途徑等資料。對所有患者HBV抗體、HCV抗體進行檢測。結果? 不同感染途徑人群合并感染發生率對比，差異具有統計學意義（P<0.05）：同性性行為患者單純HIV感染發生率最高，吸毒患者HIV+HBV感染率最高，輸血患者HIV+HCV感染率最高，HIV+HBV+HCV感染率最高者為吸毒患者。不同學歷合并感染發生率對比，差異具有統計學意義（P<0.05）：大專及以上的患者以HIV單純感染為主，高中及中專患者以HIV和HIV+HBV為主，初中及以下的患者則以合并感染為主。不同職業合并感染發生率對比，差異具有統計學意義（P<0.05）：單純HIV感染患者以自由職業及職員為主，職員在HIV+HBV感染發病率高于自由職業者及農民，農民在HIV+HCV及HIV+HBV+HCV的發病率均高于其他職業患者。結論? 男性同性戀HIV感染者中乙型肝炎病毒、丙型肝炎病毒合并感染發生率均較高，患者感染途徑、文化程度及職業的不同，合并感染情況均有顯著差異。

關鍵詞：男性同性戀;HIV感染者;乙型肝炎;丙型肝炎;感染

中圖分類號：R512.91;R512.6? ? ? ? ? ? ? ? ? ? ? ? ? ? 文獻標識碼：A? ? ? ? ? ? ? ? ? ? ? ? ? DOI：10.3969/j.issn.1006-1959.2019.06.046

文章編號：1006-1959（2019）06-0145-03

Abstract：Objective? To investigate the co-infection of hepatitis B virus （HBV） and hepatitis C virus （HCV） among HIV-infected men. Methods? A total of 157 male homosexual HIV-infected patients who were treated in the region from January 2016 to January 2018 were enrolled in this study. The cross-sectional survey was conducted to collect the gender， age， education level， and infection route of all enrolled patients. And other information. All patients were tested for HBV antibodies and HCV antibodies. Results? The incidence of co-infection in different infections was statistically significant （P<0.05）. The incidence of HIV infection was the highest in patients with homosexual behavior， the highest in HIV+HBV infection among drug users， and the highest in HIV+HCV infection in transfusion patients. The highest rate of HIV+HBV+HCV infection is drug users. The incidence of combined infections in different academic qualifications was statistically significant （P<0.05）： patients with college and above were mainly infected with HIV， and high school and secondary school patients were mainly HIV and HIV+HBV. Patients with junior high school and below. Then the main infection is combined. The incidence of concomitant infections in different occupations was statistically significant （P<0.05）：Patients with HIV-infected patients were mainly freelancers and staff. The incidence of HIV+HBV infection among staff was higher than that of freelancers and farmers. The incidence of HIV+HCV and HIV+HBV+HCV was higher in farmers than in other occupational patients. Conclusion? The incidence of hepatitis B virus and hepatitis C virus co-infection in male homosexual HIV-infected patients is high. The infection route， education level and occupation are different， and the infection status is significantly different.