過敏性紫癜合并肺炎支原體感染患兒的特征表現及治療結局分析

蔡勉珊 方炳雄 黃旭東 等

[摘要]目的 探討與分析過敏性紫癜（HSP）合并肺炎支原體感染患兒的臨床特征及治療結局情況，分析HSP復發與肺炎支原體感染的相關性。方法 從2016年3月～2017年11月在普寧市人民醫院收治的HSP患兒中，根據雙盲法隨機抽取180例患兒作為研究對象，根據患兒肺炎支原體DNA檢測結果，將其分為支原體感染組（95例），與非支原體感染組（85例）。分析臨床特征，并對患兒進行治療，比較兩組治療后生化檢驗和血常規檢驗各項指標情況，并觀察兩組的住院時間以及復發情況。結果 支原體感染組總膽固醇（TC）、天冬氨酸轉氨酶（AST）、丙氨酸氨基轉移酶（ALT）水平均高于非支原體感染組（P<0.05）;支原體感染組白細胞計數（WBC）、紅細胞計數（RBC）、血小板計數（PLT）和血紅蛋白（Hb）水平均高于非支原體感染組（P<0.05）;支原體感染組的住院時間長于非支原體感染組，且復發率高于非支原體感染組，差異均有統計學意義（P<0.05）。結論 HSP患兒復發受到肺炎支原體感染因素的影響，臨床上應盡早對HSP患兒進行肺炎支原體DNA檢測，及時診斷和治療，從而降低患兒HSP的復發率。

[關鍵詞]過敏性紫癜;肺炎支原體感染;臨床特征;甲潑尼龍;西咪替丁;氯雷他定;孟魯司特鈉;阿奇霉素

[中圖分類號] R725.5? ? ? ? ? [文獻標識碼] A? ? ? ? ? [文章編號] 1674-4721（2019）2（a）-0146-04

[Abstract] Objective To explore and analyze the clinical characteristics and treatment outcome of children with Henoch-Schnlein purpura （HSP） complicated with Mycoplasma pneumoniae infection， and to analyze the correlation between the recurrence of HSP and Mycoplasma pneumoniae infection. Methods Altogether 180 cases of patients with HSP and who received treatment in Puning People′s Hospital from March 2016 to November 2017 were selected as research objects according to the double blind method， and were divided into 95 cases of Mycoplasma infection group and 85 cases of non Mycoplasma infection group according to DNA test results of patients with Mycoplasma pneumoniae. Then， the clinical characteristics were analyzed and patients were given the treatment， and the each indexes changes of biochemical test and blood routine test after the treatment of two groups of patients were compared， and the hospitalization time and recurrence of the two groups were observed. Results The levels of total cholesterol （TC）， aspartate aminotransferase （AST） and alanine aminotransferase （ALT） in Mycoplasma infection group were higher than those in non Mycoplasma infection group（P<0.05）. The levels of white blood cell count（WBC）， red blood cell count（RBC）， platelet count（PLT） and hemoglobin （Hb） in Mycoplasma infection group were higher than those in the non Mycoplasma infection group （P<0.05）. The hospitalization time in the Mycoplasma infection group was longer than that in the non Mycoplasma infection group， and the recurrence rate was higher than that in the non-Mycoplasma infection group， the differences were statistically significant （P<0.05）. Conclusion The recurrence of patients with HSP is influenced by the infection factors of Mycoplasma pneumonia， which it is necessary to detect Mycoplasma pneumoniae DNA in patients with HSP as early as possible， and timely diagnose and treat， so as to reduce the recurrence rate of patients with HSP.