榮峰



[摘要]目的 探討地塞米松注射液在呼吸道感染患者中的應用效果。方法 選取我院2016年5月~2018年5月收治的120例呼吸道感染患者作為研究對象,按照不同治療方法分為治療組(60例)與對照組(60例)。治療組采用對癥治療聯合地塞米松注射液治療,對照組僅采用單純對照治療。比較兩組的體溫恢復情況、不良反應發生情況、生活質量SF-36評分。結果 治療組的體溫恢復時間、治療時間均短于對照組,差異有統計學意義(P<0.05);治療組的不良反應總發生率高于對照組,差異有統計學意義(P<0.05);治療組治療后的生活質量SF-36評分高于對照組,差異有統計學意義(P<0.05)。結論 臨床對呼吸道感染患者采用地塞米松注射液治療,雖可加速體溫恢復正常,從而提高生活質量,但值得注意的是,其不良反應發生率較高,建議謹慎使用。
[關鍵詞]呼吸道感染;地塞米松注射液;不良反應;對癥治療
[中圖分類號] R56? ? ? ? ? [文獻標識碼] A? ? ? ? ? [文章編號] 1674-4721(2019)2(a)-0048-03
[Abstract] Objective To explore the application effect of Dexamethasone Injection in patients with respiratory tract infection. Methods A total of 120 patients with respiratory tract infection admitted to our hospital from May 2016 to May 2018 were selected as study subjects, and divided into the treatment group (60 cases) and the control group (60 cases) according to different treatment methods. Symptomatic treatment combined with Dexamethasone Injection was used in the treatment group, while the control group was only treated with simple control. Temperature recovery, adverse reactions, and quality of life SF-36 scores were compared between the two groups. Results The temperature recovery time and treatment time of the treatment group were shorter than those of the control group, and the differences were statistically significant (P<0.05). The total incidence rate of adverse reaction of the treatment group was higher than that of the control group, and the difference was statistically significant (P<0.05). Quality of life SF-36 score in the treatment group after treatment was higher than that in the control group, the difference was statistically significant (P<0.05). Conclusion Dexamethasone Injection can accelerate the recovery of body temperature and improve the quality of life in patients with respiratory tract infection. However, it is worth noting that the adverse reaction rate is relatively high and it is recommended to be used cautiously.
[Key words] Respiratory tract infection; Dexamethasone Injection; Adverse reactions; Symptomatic treatment
上呼吸道感染是指咽喉部、鼻腔引發急性炎癥所致,具有較高的患病率,特別是在流行性感染高發時段或者是春、冬兩季[1]。該病的傳染性較強,若未能得到及時且有效控制,則容易產生諸多嚴重并發癥,對患者正常生活、工作水平產生影響,因此,加強早期預防與控制呼吸道感染病癥對加速患者早日恢復身體健康具有重大積極意義。目前,本病臨床中常用常規抗感染治療,雖具有一定成效,但效果不明顯。地塞米松屬于一種糖皮質激素類藥物,可發揮抗休克、抗炎、抗過敏等藥物作用[2-3]。但多項臨床實踐顯示,該藥的不良反應較多,受到醫學界高度重視。本研究選取我院收治的呼吸道感染患者作為研究對象,旨在探討地塞米松注射液治療的臨床現實意義,并評價治療后的不良反應發生情況,現報道如下。
1資料與方法
1.1一般資料
隨機選取2016年5月~2018年5月我院收治的120例呼吸道感染患者作為研究對象,依照不同治療方案分為治療組和對照組,各60例。治療組中,男34例,女26例;年齡20~75歲,平均(43.11±6.38)歲。對照組中,男35例,女25例;年齡18~73歲,平均(43.05±6.13)歲。所有患者均伴有程度不一的咳嗽、咳痰、發熱、鼻塞等臨床病癥。兩組的一般資料比較,差異無統計學意義(P>0.05),具有可比性。納入標準:①確診為呼吸道感染者;②積極配合本次臨床試驗者;③無其他嚴重并發癥者;④所有患者均已簽署知情同意書,且經醫院醫學倫理委員會審核批準。排除標準:①患有嚴重心血管疾病者;②年齡<15周歲者;③患有嚴重精神類疾病者。