蒲地藍(lán)消炎口服液聯(lián)合小兒豉翹清熱顆粒治療小兒上呼吸道感染臨床觀察

陳鑫

【摘 要】 目的：觀察蒲地藍(lán)消炎口服液聯(lián)合小兒豉翹清熱顆粒治療小兒上呼吸道感染的效果。方法：選取小兒上呼吸道感染患者144例為研究對象，隨機(jī)分為對照組和研究組各72例。對照組給予小兒豉翹清熱顆粒口服，觀察組在對照組基礎(chǔ)上給予蒲地藍(lán)消炎口服液。比較兩組療效、不良反應(yīng)、癥狀改善時間及治療前后腫瘤壞死因子αTNF-α和白細(xì)胞介素IL-6水平。結(jié)果：研究組總有效率明顯高于對照組，治療后兩組（TNF-α）、6（IL-6）水平均明顯降低，研究組明顯低于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）；兩組均未出現(xiàn)不良反應(yīng)。結(jié)論：蒲地藍(lán)消炎口服液聯(lián)合小兒豉翹清熱顆粒治療小兒上呼吸道感染效果較好，可快速降低血清炎性因子水平，改善患兒癥狀，且用藥無明顯不良反應(yīng)，值得推廣應(yīng)用。

【關(guān)鍵詞】 小兒；上呼吸道感染；蒲地藍(lán)消炎口服液；小兒豉翹清熱顆粒

【中圖分類號】R562 【文獻(xiàn)標(biāo)志碼】 A 【文章編號】1007-8517（2018）01-0098-03

Abstract：Objective To observe the effect of Pudilan Xiaoyan oral liquid combined with chiqiao qingre granuleon on upper respiratory tract infection in children. Methods Selected144 cases of upper respiratory tract infection in children ， and all children were randomly divided into control group and research group， each 72 patients. Children in control group were treated with chiqiao qingre granuleon， and patients in research group were treated with Pudilan Xiaoyan oral liquid based on the control group. Comparing curative effect， adverse reactions， the time of symptom improvement， and tumor necrosis factor（TNF-α）、interleukin-6（IL-6） between the two groups before and after treatment. Results The total effective rate of research group was significantly higher than that of control group， both groups of TNF-α、IL-6 were significantly lower after treatment than those before treatment， and the research group indicators were significantly lower than those in the control group， and the difference was statistically significant，， there was no statistically significant difference between the two groups （P<0.05）. There was no adverse reactions in both groups. Conclusion There is a pronounced effect of Pudilan Xiaoyan oral liquid combined with chiqiao qingre granuleon on upper respiratory tract infection in children， which can quickly reduce the levels of serum inflammatory factors， improve children symptoms， and both drugs are safe.

Keywords：Children； Upper Respiratory Tract Infection；Pudilan Xiaoyan Oral Liquid； Chiqiao Qingre Granuleon

上呼吸道感染是由病毒或細(xì)菌引起的感染性疾病，多發(fā)于嬰幼兒，冬春季節(jié)常見，多為病毒感染，少數(shù)為細(xì)菌感染或病毒感染后繼發(fā)細(xì)菌感染。其臨床癥狀主要有鼻塞、流涕、咳嗽、發(fā)熱等，多伴有嘔吐、腹瀉等[1]。臨床多使用抗生素治療，但容易產(chǎn)生耐藥性，且廣譜抗生素易引起菌群失調(diào)，出現(xiàn)腹瀉等不良反應(yīng)。小兒臟器功能發(fā)育不完善，對于抗病毒、抗菌藥物的耐受性差，可能導(dǎo)致小兒器官組織受損，從而影響發(fā)育[2]。研究表明[3]，中成藥治療上呼吸道感染效果肯定。筆者選取72例患兒，觀察蒲地藍(lán)消炎口服液聯(lián)合小兒豉翹清熱顆粒治療小兒上呼吸道感染的效果，具體報告如下。

1 資料與方法

1.1 一般資料 選取2016年6月至2017年8月我院收治的小兒上呼吸道感染患者144例為研究對象，主要表現(xiàn)為鼻塞流涕、咽喉紅腫、咳嗽、發(fā)熱等，患兒入院后進(jìn)行血液細(xì)菌培養(yǎng)和病毒血清學(xué)檢測，確定病原體所有患兒西醫(yī)符合《兒科學(xué)》診斷標(biāo)準(zhǔn)[4]，中醫(yī)屬于《中藥新藥臨床研究指導(dǎo)原則》中外感風(fēng)熱證[5]。……