桂哌齊特與甲鈷胺對糖尿病周圍神經病變患者神經傳導速度、VPT及血清指標的影響研究

羅虹

[摘要]目的 探討桂哌齊特與甲鈷胺對糖尿病周圍神經病變（DPN）患者神經傳導速度、VPT及血清指標的影響。方法 選取2015年3月～2017年3月我院收治的80例DPN患者作為研究對象，按照平行對照法分為觀察組（桂哌齊特與甲鈷胺治療）與參考組（甲鈷胺治療），每組各40例。比較兩組患者治療前后的神經傳導速度、雙下肢震動感覺閾值（VPT）水平以及血清指標變化。結果 治療前后兩組患者的神經傳導速度比較，差異有統計學意義（P<0.05）；治療后觀察組各部位的神經傳導速度明顯大于參考組，差異有統計學意義（P<0.05）；治療前后兩組患者VPT值比較，差異有統計學意義（P<0.05）；治療后觀察組的下降程度大于參考組，差異有統計學意義（P<0.05）；治療前后兩組患者血清HMGB1、Hcy、MDA、NSE、S100β水平比較，差異有統計學意義（P<0.05）；觀察組與參考組各指標比較，差異有統計學意義（P<0.05）。結論 桂哌齊特與甲鈷胺聯合治療DPN能夠促進患者微循環改善，促進受損神經功能的恢復，效果顯著。

[關鍵詞]桂哌齊特；甲鈷胺；DPN；神經傳導速度；VPT；血清指標

[中圖分類號] R587.2 [文獻標識碼] A [文章編號] 1674-4721（2018）4（b）-0050-04

Effect of Cinepazide and Mecobalamin on nerve conduction velocity，VPT and serum parameters in patients with diabetic peripheral neuropathy

LUO Hong

Department of Endocrinology，the First People′s Hospital of Fuzhou City in Jiangxi Province，Fuzhou 344000，China

[Abstract]Objective To investigate the effects of Cinepazide and Mecobalamin on the nerve conduction velocity，vibration perception threshold （VPT） and serum parameters in diabetic peripheral neuropathy （DPN） patients.Methods Eighty DPN patients treated in our hospital from March 2015 to March 2017 were selected as the subjects，and divided into observation group （Cinepazide and Mecobalamin therapy） and reference group （sole Mecobalamin），with 40 cases in each group according to the method of parallel control.The nerve conduction velocity，the VPT level and serum parameters before and after treatment were compared between the two groups.Results Before and after treatment，the nerve conduction velocity was significantly different between the two groups （P<0.05）.After the treatment，the nerve conduction velocity in various parts in the observation group was significantly greater than that of the reference group，the difference was statistically significant （P<0.05）.The VPT values of the two groups before and after treatment were significantly different （P<0.05）.After treatment，the decrease of VPT in the observation group was more remarkable compared with that in the reference group （P<0.05）.The levels of serum HMGB1，Hcy，MDA，NSE and S100β in the two groups before and after treatment were significantly different （P<0.05）.Each parameter in the observation group was statistically different from that in the reference group （P<0.05）.Conclusion Combination of cinepazide and mecobalamin in the treatment of DPN can promote microcirculation and recovery of damaged nerve function，and obtain a remarkable effect.

[Key words]Cinepazide；Mecobalamin；DPN；Nerve conduction velocity；VPT；Serum parameters