穩心顆粒治療慢性肺心病頻發房性早搏療效觀察

解建　鄧新桃　趙建祥

【摘要】目的 探討穩心顆粒治療慢性肺心病頻發房性早搏的療效。方法 選取2013年9月～2015年9月在我院住院及門診治療的92例慢性肺心病頻發房性早搏患者作為研究對象，隨機均分為觀察組和對照組，觀察組在常規治療的基礎上加用穩心顆粒治療，對照組在常規治療的基礎上加用胺碘酮治療，觀察兩組臨床癥狀改善、動態心電圖療效及不良反應發生率。結果 觀察組臨床癥狀改善及動態心電圖療效均明顯優于對照組，差異有統計學意義（P<0.05）；觀察組總不良反應率2.2%與對照組13.0%相比，差異有統計學意義（P<0.05），用藥安全性較高。結論 穩心顆粒治療慢性肺心病頻發房性早搏療效顯著，且藥物副作用少，安全性高，值得在臨床上推廣。

【關鍵詞】慢性肺心病；頻發房性早搏；穩心顆粒

【中圖分類號】R259 【文獻標識碼】B 【文章編號】ISSN.2095-6681.2018.07..02

Wenxin Granule in the treatment of chronic pulmonary heart disease with frequent atrial premature beats

XIE Jian，DENG Xin-tao，ZHAO Jian-xiang，LIU Chuan-hong

（Xinghua People's Hospital affiliated to Yangzhou University，Jiangsu Taizhou 225700，China）

【Abstract】Objective To explore the clinical effect ofWenxin Granule on chronic pulmonary heart diseasepatients with frequent atrial premature beats.Methods A total of 92patients with frequent atrial premature beats were randomized into thecontrol group treated withAmiodarone added to theconventional medicationandthe treatment group treated withWenxingranule added to theconventional medication. The therapeutic efficacy of the two groups was assessed after treatment by the observation ofclinical symptoms、Holter monitor test and adverse reactionsanalysis.Results Less clinical symptoms and better Holter results were observed in the Wenxingranule group.The total rate of adverse reactions in treatment group was 2.2%，while the rate in control group was 13.0%.There were statistical significances in clinical efficacy between the two groups （P<0.05）.Conclusion Wenxin granule has a better effect than conventional medication in the treatment of chronic pulmonary heart disease with frequent atrial premature beats， and has less adverse reactions. It is worth recommended in clinical practice.

【Key words】Wenxin Granule；Chronic pulmonary heart disease；Frequent atrial premature beats

慢性肺源性心臟病（Chronic Pulmonary Heart Disease）又稱慢性肺心病，是指由支氣管肺組織、胸廓或肺血管的慢性病變，致肺血管阻力增加，產生肺動脈高壓，繼而右心室結構或（和）功能改變的心臟病，并排除先天性心臟病和左心病變引起者。慢性肺心病在感染、缺氧、酸中毒等情況下可引起心律失常[1]，最常見的心律失常為房性心律失常，比如房性早搏、陣發性室上性心動過速等，也可出現心房撲動、心房顫動，少數患者可以出現嚴重心肌缺氧，導致心室顫動。本研究應用穩心顆粒治療慢性肺心病頻發房性早搏取得了良好的效果，現將結果報道如下。

1 資料與方法

1.1 一般資料

選擇2013年9月～2015年9月在我院住院及門診治療的慢性肺心病頻發房性早搏患者92例，其中男58例，女34例，年齡56～82歲，病程（3-17）年。隨機分成兩組，各46例。兩組性別、年齡、病程方面無顯著性差異（P>0.05）。……