嬰幼兒巨細(xì)胞病毒感染的臨床特點(diǎn)及其影響分析

張曉　李偉　屠榮良　韓曉

[摘要] 目的 分析嬰幼兒巨細(xì)胞病毒（CMV）的臨床特點(diǎn)及對(duì)嬰幼兒健康的影響。 方法 選取合并巨細(xì)胞病毒感染的嬰幼兒93例，回顧性分析患者的臨床資料，總結(jié)臨床特點(diǎn)。 結(jié)果 男性感染者59.14%，女性感染者40.86%。先天性感染26例，占27.96%；圍生期感染56例，占60.21%；出生后感染11例，占11.83%。先天性感染組合并肝炎發(fā)生率為3.85%，合并肺炎發(fā)生率為15.38%，合并全身感染發(fā)生率為19.23%，合并顱內(nèi)出血發(fā)生率為11.54%。圍生期感染組合并肝炎發(fā)生率為57.14%，合并肺炎發(fā)生率為10.71%，合并全身感染發(fā)生率為1.79%，合并顱內(nèi)出血發(fā)生率為7.14%。出生后感染組合并肝炎發(fā)生率為45.45%，合并肺炎發(fā)生率為18.18%，合并全身感染發(fā)生率為0.00%，合并顱內(nèi)出血發(fā)生率為0.00%。93例患兒中，2例先天性感染患兒死亡。隨訪患兒31例，年齡3個(gè)月～5歲，2例患兒Gesell智測(cè)略低，均為先天性感染。 結(jié)論 嬰幼兒巨細(xì)胞病毒感染多發(fā)生在圍生期，容易合并其他各種感染，先天性巨細(xì)胞病毒感染預(yù)后相對(duì)較差，臨床上應(yīng)早期防治。

[關(guān)鍵詞] 嬰幼兒；巨細(xì)胞病毒；感染；臨床特點(diǎn)

[中圖分類號(hào)] R725.1 [文獻(xiàn)標(biāo)識(shí)碼] B [文章編號(hào)] 1673-9701（2017）14-0053-04

[Abstract] Objective To analyze the clinical characteristics of infantile cytomegalovirus（CMV） and its effect on infantile health. Methods 93 cases of infants with cytomegalovirus infection were selected. The patients' clinical data were retrospectively analyzed， and the clinical characteristics were summarized. Results Infected male infants accounted for 59.14%； infected female infants accounted for 40.86%. Congenital infection was in 26 cases， accounting for 27.96%； perinatal infection was in 56 cases， accounting for 60.21%； infection after birth was in 11 cases， accounting for 11.83%. In the congenital infection group， the incidence rate of complicated hepatitis was 3.85%， and the incidence rate of complicated pneumonia was 15.38%. The incidence rate of complicated systemic infection was 19.23%， and the incidence rate of complicated intracranial hemorrhage was 11.54%. In the perinatal infection group， the incidence rate of complicated hepatitis was 57.14%， and the incidence rate of complicated pneumonia was 10.71%. The incidence rate of complicated systemic infection was 1.79%， and the incidence rate of complicated intracranial hemorrhage was 7.14%. In the group of infection after birth， the incidence rate of complicated hepatitis was 45.45%， and the incidence rate of complicated pneumonia was 18.18%. The incidence rate of complicated systemic infection was 0.00%， and the incidence rate of complicated intracranial hemorrhage was 0.00%. Of the 93 patients， 2 cases died of congenital infection. 31 infants were followed-up， aged 3 months to 5 years old. 2 infants were with low intelligence based on the Gesell intelligence test， who were both with congenital infection. Conclusion Infantile cytomegalovirus infection mostly occurs in the perinatal period， which is prone to be complicated with other types of infections. Congenital cytomegalovirus infection has a relatively poor prognosis， which should be given early prevention and treatment clinically.