血清白介素6水平與抑郁發(fā)作的關(guān)系

張載福,楊帆,王衛(wèi)平,施波,趙俊雄,呂望強(qiáng),喻躍國,賈玉萍,張晨

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血清白介素6水平與抑郁發(fā)作的關(guān)系

張載福,楊帆,王衛(wèi)平,施波,趙俊雄,呂望強(qiáng),喻躍國,賈玉萍,張晨

目的探討血清白介素6(IL-6)水平與抑郁發(fā)作的關(guān)系。方法檢測及比較單相抑郁障礙63例(單相抑郁組)、雙相障礙抑郁80例(雙相抑郁組)及健康對照者42名(對照組)血清IL-6水平；采用漢密爾頓抑郁量表(HAMD)評定單相與雙相抑郁發(fā)作患者抑郁癥狀,分析血清IL-6水平與HAMD評分的關(guān)系。結(jié)果病例組和對照組血清IL-6水平分別為(64.56±7.10)ng/L和(22.54±2.99)ng/L,兩組組間差異具有統(tǒng)計(jì)學(xué)意義(F=1362.51,P<0.01)。單相抑郁組和雙相抑郁組血清IL-6水平分別為(65.11±7.21)ng/L和(63.85±6.95)ng/L,兩組間差異無統(tǒng)計(jì)學(xué)意義(P>0.05)。抑郁發(fā)作患者血清IL-6水平與HAMD評分呈正相關(guān)(r=0.19,P=0.025)。結(jié)論單相與雙相抑郁發(fā)作患者血清IL-6水平顯著升高,并與其病情的嚴(yán)重程度一致。

白介素6； 單相抑郁； 雙相抑郁

Abstract：Objective： To investigate the relationship between serum IL-6 protein and unipolar depression as well as bipolar depression.Method：143 patients with depressive episode,including 63 ones with unipolar depression (unipolar group) and 80 ones with bipolar depression (bipolar group),and 42 healthy controls (control group) were enrolled.Depressive symptoms were evaluated using Hamilton rating scale for depression (HAMD) and serum IL-6 levels were measured.Results：IL6 levels in case and control groups were (64.56±7.10) ng/L and (22.54±2.99) ng/L,respectively.There was significant difference in IL6 levels between these groups (F=1362.51,P<0.01).IL6 levels in unipolar and bipolar groups were (65.11±7.21) ng/L and (63.85±6.95) ng/L.There were no significant difference in IL6 levels between the unipolar and bipolar groups (P>0.05).There was a positive correlation between the serum level of IL6 and HAMD total score in patients with depressive episode (r=0.19,P=0.025).Conclusion：Serum IL-6 levels increase in patients with unipolar or bipolar depression and correlate with severity of depression.

Keywords： interleukin 6; unipolar depression; bipolar depression

研究顯示情緒障礙和應(yīng)激事件對免疫功能產(chǎn)生影響,免疫功能的改變也會反向成為抑郁障礙發(fā)生的潛在病因。目前抑郁障礙的病理機(jī)制之一的神經(jīng)免疫假說[1]認(rèn)為,抑郁障礙是一種心理神經(jīng)免疫紊亂性疾病,與免疫系統(tǒng)激活有關(guān),外周免疫激活通過釋放前炎性細(xì)胞因子導(dǎo)致與抑郁障礙相關(guān)的各種行為、神經(jīng)內(nèi)分泌和神經(jīng)生化改變[2]。遺傳學(xué)研究[3]發(fā)現(xiàn)白介素-6(IL-6)基因是抑郁障礙的重要易感基因；薈萃分析[4]也提示外周血IL-6水平變化與抑郁癥發(fā)病具有相關(guān)性；基于單、雙相抑郁的治療方案和預(yù)后差異,目前認(rèn)為兩者間可能存在不同的發(fā)病機(jī)制,屬于不同的疾病譜系[5]。本研究比較單相與雙相抑郁發(fā)作患者血清IL-6水平,探索其作為臨床診斷單、雙相抑郁發(fā)作生物學(xué)標(biāo)記物的可行性。……