SCC和Ki67在宮頸鱗癌不同分期的表達及其關系

陳紅香　隋霜　才仁　王琳　劉江超　古麗加娜提　王芬　沈澤虹　瑪依努爾·尼牙孜

·論著·

SCC和Ki67在宮頸鱗癌不同分期的表達及其關系

陳紅香隋霜才仁王琳劉江超古麗加娜提王芬沈澤虹瑪依努爾·尼牙孜

目的：探討腫瘤標志物鱗狀細胞癌抗原（SCC）和Ki67在宮頸鱗癌不同分期的表達及其關系。方法：收集新疆維吾爾自治區人民醫院婦科宮頸鱗癌130例，早期宮頸鱗癌組60例（包括ⅠB1、ⅡA＜4 cm）和中-晚期宮頸鱗癌組70例（包括ⅡB、Ⅲ、ⅣA期），宮頸炎為對照組50例。采用化學發光法檢測SCC和免疫組化法檢測Ki67。結果：宮頸鱗癌組血清SCC的含量明顯高于宮頸炎組，差異有統計學意義（P＜0.05），中-晚期宮頸鱗癌明顯高于早期宮頸鱗癌，差異有統計學意義（P＜0.05）。宮頸鱗癌組Ki67的表達明顯高于宮頸炎組，差異有統計學意義（P＜0.05），中-晚期宮頸鱗癌明顯高于早期宮頸鱗癌，差異有統計學意義（P＜0.05）。中-晚期宮頸鱗癌高表達占94.28%，早期宮頸鱗癌低表達占71.67%。結論：隨著宮頸鱗癌臨床分期進展，SCC和Ki67的表達逐漸升高。Ki67明顯高表達提示中-晚期宮頸鱗癌可能性大，Ki67低表達提示早期宮頸鱗癌可能性大。

SCC；Ki67；宮頸鱗癌；臨床分期

【Abstract】Objective：To investigate the expression and relationship between squamous cell carcinoma associated antigen（SCC），Ki67 in differentclinical stage of cervicalsquamous cell carcinoma.M ethods：We collected in Xinjiang Uygur Autonomous Region people's hospitaldepartmentofgynaecology cervicalsquamouscellcarcinoma in 130 cases（according to FIGO clinicalstage isdivided intoearly cervicalsquamous cell carcinoma group in 60 cases（includingⅠB1、ⅡA＜4 cm）and in-advanced squamouscervical carcinoma group 70 cases（includingⅡB、Ⅲ、ⅣA）.Cervicitisas the controlgroup of50 cases.Chemical luminescencemethodwasused todetectSCCand immunohistochemicalmethod for detection of Ki67.Results：Cervicalsquamous cell carcinomagroup，theserum levelsof SCCof the contentswere significantly higher in chronic cervicitis group，the differencewas statistically significant（P＜0.05）.In advanced cervical squamous cell carcinoma was significantly higher than thatofearly cervicalsquamous cell carcinoma，the difference is statistically significant（P＜0.05）；cervicalsquamous cell carcinoma Ki67 expressionwassignificantly higher in chronic cervicitisgroup，the difference isstatistically significant（P＜0.05）.In advanced cervicalsquamous cell carcinomawassignificantly higher than thatofearly cervicalsquamous cell carcinoma，and the difference is statistically significant（P＜0.05）.In themiddle and late stageofcervicalsquamous cell carcinomawasmainly high expressionmainly accounted for94.28%，low expression ofearly cervicalsquamous cell carcinoma accounted for 71.67%.Conclusion：Ki67 and SCC in cervicalsquamouscellcarcinomawith clinicalstage，SCCand Ki67 expression gradually increased.Ki67washighlyexpressed in thehigh expression ofadvanced cervicalsquamouscellcarcinoma，Ki67 low expression ofearly cervicalsquamouscellcarcinoma is thepossibilityof large.

【Key words】SCC；Ki67；cervicalsquamous cell carcinoma；clinicalstage

宮頸癌是女性生殖系統的惡性腫瘤之一，屬于高發疾病［1］。宮頸鱗癌的診斷因子或者標志物鱗狀細胞癌相關抗原（squamous cell carcinoma associated antigen，SCC）被認為是特異性較高的診斷標志物之一。研究發現Ki67是一種核抗原，它與細胞的增殖息息相關，檢測Ki67的表達能夠反映出宮頸癌細胞的增殖情況。宮頸癌目前仍采用臨床分期，臨床分期一般是在治療前確定，且定好的臨床分期往往不發生變化。……