“生物膜形態發生及維持的分子機制”立項報告

胡俊杰 張渺

摘 要：內質網是一個在細胞內的普遍存在的生物膜系統，聯系了細胞質、細胞核以及細胞膜等重要細胞結構。內質網承擔了膜蛋白和分泌性蛋白的轉錄、折疊、修飾和轉運，同時也是蛋白質質量的監控點。它還具有糖類脂類合成、鈣調控和毒素降解的重要功能。內質網功能的紊亂能夠導致糖尿病等代謝疾病，以及多種神經退行性疾病。由于形態的多樣性及功能的重要性，內質網成為研究生物膜結構與功能的首選目標，對內質網結構與功能的研究與攻克重大人類疾病休戚相關，也是膜生物學國際科研的前沿。我們將以內質網的結構為重點，系統研究細胞內膜精細結構形成和維持的關鍵機制，并深入探索膜結構融合的機制，最終為闡述相關的重要細胞功能提供新的理論基礎。

關鍵詞：內質網 成管膜蛋白 膜融合

"Molecular Mechanism for Biomembrane Formation and Maintainance"/Project Report

Hu Junjie Zhang Miao

（Nankai University）

Abstract：The endoplasmic reticulum （ER） is an intracellular membrane system existed throughout the cytoplasm of cells. It forms connections between the cytoplasm， nucleus， and other important cellular membrane structures. The ER is not only required for the transcription， folding， modification and transport of the membrane proteins and secretory proteins， but also responsible for protein quality control. At the meantime it has important functions including synthesis of carbohydrate and lipid， calcium regulation and toxin degradation. The disorders of Endoplasmic reticulum function can result in several metabolic diseases like diabetes， and various neurodegenerative diseases. Given the structurally diversity and functionally importance of the endoplasmic reticulum， it became the concentration and leading edge of the biological membrane structure and function research， which is closely related to overcoming the major human diseases. We will focus on the structure of the endoplasmic reticulum， and systematically study the key mechanisms of intracellular membrane formation， maintenance， and fusion. Ultimately our study may provide new theoretical foundation for ER-related important cellular functions.

Key Words：Endoplasmic reticulum；Tubule-shaping proteins；Homotypic fusion

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