高分子體系中物理機(jī)制與其應(yīng)用探索

馬余強(qiáng) 張澤新 胡志軍 陳康 賈玉璽

摘 要：高分子體系的大量外在性質(zhì)是由其物理機(jī)制控制的，研究高分子體系中的物理機(jī)制對其應(yīng)用有著重要的促進(jìn)意義。我們在對高分子膠體的非晶液-固轉(zhuǎn)變行為等基礎(chǔ)問題進(jìn)行深化研究的同時，也對高分子納米微陣列的物理學(xué)性質(zhì)、枝狀高分子及一般軟或硬膠體載藥應(yīng)用中的物理機(jī)制、碳纖維復(fù)合材料玻璃化轉(zhuǎn)變等高分子應(yīng)用問題進(jìn)行了探索性研究。結(jié)合分子動力學(xué)模擬、非線性Langevin方程等理論模擬方法和熒光、電鏡等實驗方法，這些研究深入發(fā)展了硬球膠體的玻璃化轉(zhuǎn)變、應(yīng)力響應(yīng)等理論。并且具體發(fā)現(xiàn)：高分子膠體的形狀對其自組織性質(zhì)有顯著影響；納米微陣列的尺寸可調(diào)節(jié)高分子主轉(zhuǎn)變等物理性質(zhì)；枝狀分子的pH載藥響應(yīng)效應(yīng)；膠體顆粒旋轉(zhuǎn)、磷脂膜排布等因素在膠體內(nèi)吞中的作用；碳纖維復(fù)合材料玻璃化轉(zhuǎn)變可用于誘導(dǎo)形狀記憶效應(yīng)。從廣度和深度，我們深化了高分子體系中物理機(jī)制的認(rèn)識，將為其發(fā)展應(yīng)用提供重要基礎(chǔ)。

關(guān)鍵詞：高分子 膠體 納米微陣列 枝狀分子 相變 磷脂膜

Exploration of the Physical Mechanisms in Polymer System and Their Applications

Ma Yuqiang1 Zhang Zexin2 Hu Zhijun2 Chen Kang2 Jia Yuxi3

（1.Department of Physics， Nanjing University；2.Center for Soft Condensed Matter & Interdisciplinary Research，Suzhou University；

3.School of Materials Science and Engineering， Shandong University）

Abstract：A great many properties of polymers are controlled by physical mechanism. Understanding these mechanisms will contribute to the application of polymers. In basic study， we have researched deep into the liquid-solid transition of polymer colloids； while in application study， we mainly explored the physical property of polymer-based nano-pattern， the physical interaction mechanism of dendrimer carrier or normal solid/soft colloid in drug delivery， and the application of the glass transition of carbon fibres. Combining theory/simulation （i.e. DPD， nonlinear Langevin equation） with experiment （i.e. fluorescence， electron microscope） methods， we have developed the glass transition， stress-response theories of hard spheres. It is also found that： the shape decides the colloid self-assemble behavior； the size of the polymer nano-array can influence the physical property， such as main transition， of the system； the pH-dependent drug capsulation property of dendrimer in drug delivery； the influence of the rotation of colloid and lipid packing in particle endocytosis； and the glass transition of carbon fibre can be used in memory of the original shape. In depth and width， our studies advanced the understanding of physical mechanisms in polymer system， which will provide important reference for its further applications.

Key Words：Polymer； Colloid； Nano-pattern； Dendrimer； Phase transition； Lipid membrane

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