Short-term Ocular Toxicity and Eye Irritation Tests Following Application of Sufentanil in Rabbits

Hongbin Chen， Zhenghua Chen， Ying Xu

Zhongshan Ophthalmic Center， Sun Yat-Sen University， Guangzhou 510060， China

Introduction

Materials and methods

Animal and grouping

Medication

Experimental methods

Observational index

Results

Grading of eye irritation

Table 1 Comparison of eye irritation in the control and experimental groups at 14 d after drug administration

Table 2 Comparison of eye irritation in the control and experimental groups at 30 d after drug administration

Slit-lamp examination

Corneal endothelial counting

Pathological examination

Discussion

Figure 1 Comparison of anterior segment parameters in the control（vehicle only） and experimental（10 μg sufentanil） groups at 14 d after sufentanil administration．

Figure 2 Comparison of anterior segment parameters in the control（vehicle only） and experimental（10 μg sufentanil） groups at 30 d after sufentanil administration．Control： A-D； Experimental： E-H．

Figure 3 Comparison of corneal endothelial counts in the control （vehicle only） and the experimental （10 μg sufentanil） groups at 14 d after sufentanil administration．Control：A；Experimental：B．

Figure 4 Comparison of corneal endothelial counts in the control （vehicle only） and the experimental （10 μg sufentanil） groups at 30 d after sufentanil administration．Control：A； Experimental： B．

Figure 5 Comparison of pathological parameters in the control （vehicle only） and the experimental （10 μg sufentanil）groups at 14 d after sufentanil administration．

Figure 6 Comparison of pathological parameters in the control （vehicle only） and the experimental （10 μg sufentanil）groups at 30 d after sufentanil administration．