補(bǔ)腎調(diào)經(jīng)活血中藥口服結(jié)合灌腸對(duì)子宮內(nèi)膜異位癥痛經(jīng)積分的影響

李錦繡

[摘要] 目的 探討補(bǔ)腎調(diào)經(jīng)活血中藥口服結(jié)合灌腸對(duì)子宮內(nèi)膜異位癥（EMs）痛經(jīng)積分的影響。 方法 將2012年3月～2013年6月本院診治的90例EMs患者納入研究，按隨機(jī)數(shù)字表法分成觀察組與對(duì)照組，每組各45例。觀察組采用中藥口服結(jié)合灌腸治療；對(duì)照組采用孕三烯酮膠囊治療。比較兩組的療效、血清炎癥因子IL-2、IL-10與瘦素水平及痛經(jīng)積分的變化情況。結(jié)果 觀察組的總有效率為91.11%，明顯高于對(duì)照組的75.56%（P<0.05）；觀察組的IL-2水平明顯高于對(duì)照組，IL-10水平、瘦素水平均明顯低于對(duì)照組（P<0.05），治療1、2、3個(gè)月后的痛經(jīng)積分均明顯低于對(duì)照組（P<0.05）。 結(jié)論 中藥口服結(jié)合灌腸治療EMs可有效減輕炎癥，緩解患者的痛經(jīng)。

[關(guān)鍵詞] 子宮內(nèi)膜異位癥；中藥；灌腸；痛經(jīng)積分

[中圖分類號(hào)] R711.71 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 1674-4721（2014）04（a）-0126-03

[Abstract] Objective To investigate influence of oral administration of Bushen tiaojing huoxue of traditional Chinese medicine combined with enema on dysmenorrhea integral of endometriosis. Methods 90 patients with EMs from March 2012 to June 2013 in our hospital were randomly divided into the observation group （n=45） and the control group （n=45） according to the random number table method.The observation group was treated with oral administration of traditional Chinese medicine combined with enema while the control group was treated with gestrinone capsule.The clinical efficacy，the level of IL-2，IL-10 of serum inflammatory factor and leptin and change of dysmenorrhea integral of the two groups were compared. Results The total effective ratein the observation group （91.11%） was significantly higher than that in the control group （75.56%） （P<0.05）；the level of IL-2 in the observation group was significantly higher than that in the control group，the level of IL-10 and leptin in the observation group were significantly lower than that in the control group，the dysmenorrhea integral after 1，2 and 3 months treatment in the observation group was significantly lower than that in the control group （P<0.05）. Conclusion The oral administration of traditional Chinese medicine combined with enema treating EMs can reduce inflammation and alleviate dysmenorrhea.

[Key words] Endometriosis；Traditional Chinese medicine；Enema；Dysmenorrhea integral

子宮內(nèi)膜異位癥（endometriosis，EMs）是指子宮內(nèi)膜組織生長在子宮腔被覆黏膜以外時(shí)所引起的良性病變，以繼發(fā)性、進(jìn)行性痛經(jīng)為主要表現(xiàn)[1]，伴月經(jīng)紊亂、性交不適、不孕不育等。EMs主要見于育齡婦女，隨著人工流產(chǎn)、放環(huán)節(jié)育等手術(shù)增多，其發(fā)病率日漸增高，病程纏綿、易復(fù)發(fā)[2]，嚴(yán)重影響女性健康和生活質(zhì)量。如何有效消除病灶、緩解痛經(jīng)、促進(jìn)生育成為治療EMs的關(guān)鍵問題，西醫(yī)臨床常給予口服孕三烯酮膠囊治療，本院嘗試采用中藥口服結(jié)合灌腸治療，通過對(duì)比研究兩種方案的臨床效果，為中醫(yī)治療EMs提供新思路。

1 資料與方法

1.1 一般資料

選擇2012年3月～2013年6月本院診治的EMs患者90例納入研究，均符合中華醫(yī)學(xué)會(huì)制訂的《子宮內(nèi)膜異位癥的診斷與治療規(guī)范》相關(guān)標(biāo)準(zhǔn)[3]。按照就診時(shí)間將EMs患者依次編號(hào)0～90，并采用隨機(jī)數(shù)字表法將其分成兩組：觀察組45例，年齡20～47（35.1±8.9）歲，未婚11例、已婚34例，病程0.5～8（4.3±2.8）年，痛經(jīng)積分8～15（11.03±4.52）分；對(duì)照組45例，年齡19～48（34.8±9.1）歲，未婚13例、已婚32例，病程0.8～10（4.5±2.7）年，痛經(jīng)積分7～15（10.98±4.51）分。……