李錦繡
[摘要] 目的 探討補腎調經活血中藥口服結合灌腸對子宮內膜異位癥(EMs)痛經積分的影響。 方法 將2012年3月~2013年6月本院診治的90例EMs患者納入研究,按隨機數字表法分成觀察組與對照組,每組各45例。觀察組采用中藥口服結合灌腸治療;對照組采用孕三烯酮膠囊治療。比較兩組的療效、血清炎癥因子IL-2、IL-10與瘦素水平及痛經積分的變化情況。結果 觀察組的總有效率為91.11%,明顯高于對照組的75.56%(P<0.05);觀察組的IL-2水平明顯高于對照組,IL-10水平、瘦素水平均明顯低于對照組(P<0.05),治療1、2、3個月后的痛經積分均明顯低于對照組(P<0.05)。 結論 中藥口服結合灌腸治療EMs可有效減輕炎癥,緩解患者的痛經。
[關鍵詞] 子宮內膜異位癥;中藥;灌腸;痛經積分
[中圖分類號] R711.71 [文獻標識碼] A [文章編號] 1674-4721(2014)04(a)-0126-03
[Abstract] Objective To investigate influence of oral administration of Bushen tiaojing huoxue of traditional Chinese medicine combined with enema on dysmenorrhea integral of endometriosis. Methods 90 patients with EMs from March 2012 to June 2013 in our hospital were randomly divided into the observation group (n=45) and the control group (n=45) according to the random number table method.The observation group was treated with oral administration of traditional Chinese medicine combined with enema while the control group was treated with gestrinone capsule.The clinical efficacy,the level of IL-2,IL-10 of serum inflammatory factor and leptin and change of dysmenorrhea integral of the two groups were compared. Results The total effective ratein the observation group (91.11%) was significantly higher than that in the control group (75.56%) (P<0.05);the level of IL-2 in the observation group was significantly higher than that in the control group,the level of IL-10 and leptin in the observation group were significantly lower than that in the control group,the dysmenorrhea integral after 1,2 and 3 months treatment in the observation group was significantly lower than that in the control group (P<0.05). Conclusion The oral administration of traditional Chinese medicine combined with enema treating EMs can reduce inflammation and alleviate dysmenorrhea.
[Key words] Endometriosis;Traditional Chinese medicine;Enema;Dysmenorrhea integral
子宮內膜異位癥(endometriosis,EMs)是指子宮內膜組織生長在子宮腔被覆黏膜以外時所引起的良性病變,以繼發性、進行性痛經為主要表現[1],伴月經紊亂、性交不適、不孕不育等。EMs主要見于育齡婦女,隨著人工流產、放環節育等手術增多,其發病率日漸增高,病程纏綿、易復發[2],嚴重影響女性健康和生活質量。如何有效消除病灶、緩解痛經、促進生育成為治療EMs的關鍵問題,西醫臨床常給予口服孕三烯酮膠囊治療,本院嘗試采用中藥口服結合灌腸治療,通過對比研究兩種方案的臨床效果,為中醫治療EMs提供新思路。
1 資料與方法
1.1 一般資料
選擇2012年3月~2013年6月本院診治的EMs患者90例納入研究,均符合中華醫學會制訂的《子宮內膜異位癥的診斷與治療規范》相關標準[3]。按照就診時間將EMs患者依次編號0~90,并采用隨機數字表法將其分成兩組:觀察組45例,年齡20~47(35.1±8.9)歲,未婚11例、已婚34例,病程0.5~8(4.3±2.8)年,痛經積分8~15(11.03±4.52)分;對照組45例,年齡19~48(34.8±9.1)歲,未婚13例、已婚32例,病程0.8~10(4.5±2.7)年,痛經積分7~15(10.98±4.51)分。……