基于國家專利的中藥外治復(fù)方治療痛風性關(guān)節(jié)炎的用藥規(guī)律研究

黃春霞 彭記棚 宋云云 李丹 王敏慧 易寒知 陳昌明 姚血明

【摘 要】目的：基于中醫(yī)傳承計算平臺V3.0挖掘國家專利數(shù)據(jù)庫中治療痛風性關(guān)節(jié)炎的中藥外治復(fù)方，分析其組方用藥規(guī)律。方法：檢索國家知識產(chǎn)權(quán)局中國專利公布網(wǎng)站中治療痛風性關(guān)節(jié)炎的專利中藥外治復(fù)方數(shù)據(jù)，采用Excel 2021建立數(shù)據(jù)庫，進行中藥頻次及功效統(tǒng)計，運用中醫(yī)傳承計算平臺V3.0進行組方規(guī)律、潛在新處方等分析并進行復(fù)雜網(wǎng)絡(luò)圖展示。結(jié)果：篩選出治療痛風性關(guān)節(jié)炎的專利中藥復(fù)方269首，涉及中藥431味。使用頻次居前3位的藥物分別是黃柏、紅花、冰片，四氣以溫性為主，五味以苦為主，歸經(jīng)以肝經(jīng)、脾經(jīng)為主。中藥類別以活血化瘀藥、清熱藥、祛風除濕藥為主。高頻藥物組合以“乳香、沒藥”“黃柏、大黃”“大黃、冰片”等為主。重要關(guān)聯(lián)規(guī)則有“紅花、沒藥→乳香”，“沒藥→乳香”，“黃柏、冰片→大黃”等。核心組合有“紅花-當歸-雞血藤-羌活-防風-杜仲”等。方劑聚類分析得到可能的新處方組合5首。結(jié)論：專利中藥外治復(fù)方主要通過活血化瘀、清熱解毒、祛風除濕等功用治療痛風性關(guān)節(jié)炎，在新藥研發(fā)時，可考慮使用黃柏、紅花、冰片等作為處方核心藥物配伍加減。

【關(guān)鍵詞】 痛風性關(guān)節(jié)炎；中藥外治復(fù)方；專利；數(shù)據(jù)挖掘；中醫(yī)傳承計算平臺

A Study on the Medication Rules of TCM External Treatment Formula for Gouty Arthritis Based on National Patents

HUANG Chun-xia，PENG Ji-peng，SONG Yun-yun，LI Dan，WANG Min-hui，YI Han-zhi，CHEN Chang-ming，

YAO Xue-ming

【ABSTRACT】Objective：Based on the traditional Chinese medicine（TCM）inheritance computing platform V3.0，this study aims to explore the TCM external treatment formulas for gouty arthritis in the national patent database，and analyze their medication rules.Methods：The data of external treatment prescriptions of patent Chinese medicine for gouty arthritis in the Chinese patent publication website of the China National Intellectual Property Administration were retrieved，and a database was established in Excel 2021 to conduct statistics on the frequency and efficacy of Chinese medicine.The traditional Chinese medicine inheritance computing platform V3.0 was used to analyze the rules of prescri-ption and potential new prescriptions，and?display complex network diagrams.Results：

Two hundred and sixty-nine patented TCM formulas were screened for the treatment of gouty arthritis，involving 431 Chinese medicines.The top three medicines with the highest frequency of use are Huangbai（Cortex Phellodendri Chinensis），Honghua（Flos Carthami），and Binpian（Borneolum

Syntheticum）.Among the four qi，warm is the main one;among the five flavors，bitter，and of the channel entry，the liver and spleen channels.The main Chinese medicines are those that activate blood，remove stasis，clear heat，dispel wind and eliminate dampness.The high-frequency medicinal combinations mainly include "Ruxiang（Olibanum），Moyao（Myrrha）" "Huangbai（Cortex Phellodendri Chinensis），Dahuang（Radix et Rhizoma Rhei）" "Dahuang（Radix et Rhizoma Rhei），Bingpian（Borneolum Syntheticum）" Important association rules include "Honghua（Flos Carthami），Moyao（Myrrha）→Ruxiang（Olibanum）" "Moyao（Myrrha）→Ruxiang（Olibanum）" and "Huangbai（Cortex Phellodendri Chinensis），Bingpian（Borneolum Syntheticum） → Dahuang（Radix et Rhizoma Rhei）".The core combinations include "Honghua（Flos Carthami）-Danggui（Radix Angelicae Sinensis）-Jixueteng（Caulis Spatholobi）-Qianghuo（Rhizoma et Radix Notopterygii）-Fangfeng（Radix Saposhnikoviae）-Duzhong（Cortex Eucommiae）".Five possible new prescription combinations were identified through formula clustering analysis.Conclusion：Patented TCM external treatment formulas mainly treat gouty arthritis through functions such as promoting blood circulation and removing blood stasis，clearing heat and resolving toxins，dispelling wind and eliminating dampness.When developing new medicines，it is possible to consider using Huangbai，Honghua，Bingpian as the core prescription medicines together with modifications.

【Keywords】 gouty arthritis;TCM external treatment formula;patents;data mining;traditional Chinese medicine inheritance computing platform

痛風性關(guān)節(jié)炎（gouty arthritis，GA）是一種常見的由嘌呤代謝紊亂引起血液中尿酸含量升高并沉積在關(guān)節(jié)和組織中的炎癥性疾病。痛風的主要病理特征是單鈉尿酸鹽晶體的慢性沉積，臨床特征是單鈉尿酸鹽晶體引起的炎癥反應(yīng)［1］。……