Coinfection with hepatic cystic and alveolar echinococcosis with abdominal wall abscess and sinus tract formation: A case report

Miao-Miao Wang,Xiu-Qing An,Jin-Ping Chai,Jin-Yu Yang,Ji-De A,Xiang-Ren A

Abstract BACKGROUND Hepatic cystic and alveolar echinococcosis coinfections,particularly with concurrent abscesses and sinus tract formation,are extremely rare.This article presents a case of a patient diagnosed with this unique presentation,discussing the typical imaging manifestations of both echinococcosis types and detailing the diagnosis and surgical treatment experience thereof.CASE SUMMARY A 39-year-old Tibetan woman presented with concurrent hepatic cystic and alveolar echinococcosis,accompanied by abdominal wall abscesses and sinus tract formation.Initial conventional imaging examinations suggested only hepatic cystic echinococcosis,but intraoperative and postoperative pathological examination revealed the coinfection.Following radical resection of the lesions,the patient’s condition improved,and she was discharged soon thereafter.Subsequent outpatient follow-ups confirmed no recurrence of the hydatid lesion and normal surgical wound healing.Though mixed hepatic cystic and alveolar echinococcosis with abdominal wall abscesses and sinus tract formations are rare,the general treatment approach remains consistent with that of simpler infections of alveolar echinococcosis.CONCLUSION Lesions involving the abdominal wall and sinus tract formation,may require radical resection.Long-term prognosis includes albendazole and follow-up examinations.

Key Words: Cystic echinococcosis;Alveolar echinococcosis;Abdominal wall abscess;Surgical treatment;Sinus tract;Case report

INTRODUCTION

Echinococcosis is prevalent in pastoral areas like northwest and southwest China,with an average prevalence of approximately 1.08% in western China[1].Two types of hepatic echinococcosis exist: Cystic echinococcosis (CE) caused byEchinococcus granulosus(E.granulosus),and alveolar echinococcosis (AE) caused byEchinococcus multilocularis(E.multilocularis).Clinical diagnosis relies primarily on imaging and immunological tests.Imaging typically involves abdominal ultrasonography (US) and computed tomography (CT),while immunological detection employs enzyme-linked immunosorbent assay (ELISA)[2-4].Definitive diagnosis requires pathological examination.

Currently,no established guidelines or general consensus exists for treating coinfections with both echinococcosis types,though radical resection is widely considered optimal[5-7].Such coinfections are rare,representing only 0.92% of all hepatic echinococcosis cases,and can be difficult to diagnose and manage[4].To date,only five such cases have been documented at Qinghai Provincial People's Hospital,China (Table 1).Notably,only one case involved concurrent abdominal wall invasion and sinus tract formation.

Table 1 Clinical data of five patients

This report details the diagnosis and treatment of a patient with a mixed hepatic echinococcosis infection,presenting with abdominal wall invasion and sinus tract formation,managed at the General Surgery Department of Qinghai Provincial People's Hospital.

CASE PRESENTATION

Chief complaints

A 39-year-old Tibetan woman presented to our hospital with intermittent upper abdominal pain and discomfort for over a month,worsening in the past week.

History of present illness

The patient had intermittent epigastric distension and pain in January without any obvious cause,not accompanied by nausea,vomiting,fever and other discomforts,and did not undergo formal diagnosis and treatment,and the above symptoms worsened a week ago,so the patient came to our outpatient clinic,and the outpatient clinic was admitted to the department of our department with "abdominal pain to be investigated",and the patient was in a clear state of mind since the onset of the disease,his mental state was clear,and the spirit was fine,and he had normal urination and defecation,and he did not see any significant reduction of his body weight in recent days.Since the onset of the disease,he has been in a clear state of mind,with a normal spirit,normal bowel movements and no significant weight loss.

Physical examination

Physical examination revealed normal skin,sclerae,palpebral conjunctiva,heart,and lungs.However,an abdominal microbulge,skin rupture with pus outflow,and tenderness were found 5.0 cm above the umbilicus (Figure 1A).No abdominal varices,gastrointestinal peristalsis,or swelling were observed,but umbilical secretions and decreasedabdominal breathing were present.Upper abdominal and periumbical tenderness,rebound pain,and muscle tension were noted,while the rest of the abdomen was unremarkable.

Figure 1 Preoperative lesions and postoperative incisions. A: Preoperative site of the patient's abdominal wall abscess;B: Postoperative abdominal wall abscess site.Note: The white arrows indicates the site of the abdominal wall abscess sinus tract.

Laboratory examinations

Initial laboratory tests showed: Red blood cells,5.98 × 1012cells/L;white blood cells,5.54 × 1012cells/L;hemoglobin,167 g/L;and platelet count,240 × 109cells/L.Liver function tests revealed: Alanine aminotransferase,9 U/L;aspartate aminotransferase,13 U/L;total bilirubin,7.2 mol/L;direct bilirubin,1.4 mol/L;indirect bilirubin,5.8 mol/L;albumin,32.2 g/L;and cholinesterase,6140 U/L.A hydatid ELISA test yielded a positive result.

Imaging examinations

Abdominal color Doppler US revealed a 51 mm × 40 mm solid mass with a hyperechoic rim in the right hepatic lobe,suggestive of CE consolidation.Abdominal CT scan confirmed echinococcosis in the left lobe and anterior liver space,adhesion to the diaphragm,and a subxiphoid abscess with adjacent abdominal wall swelling.Scattered calcifications were identified within the right lobe CE (Figure 2A and B).

Figure 2 Pre-and postoperative imaging. A: Preoperative computed tomography (CT) images;B: Preoperative CT images;C: Postoperative CT images.Note: The white arrows indicate the site of the abdominal wall abscess sinus tract,the blue arrows indicate the site of the hepatic alveolar echinococcosis lesion,and the yellow arrows indicates the site of the hepatic cystic echinococcosis lesion.

Further diagnostic work-up

Based on these findings,a diagnosis of hepatic CE with abdominal wall abscesses was made.The preoperative evaluation showed normal cardiopulmonary function and Child–Pugh grade A (5 points).

Intraoperatively (Figure 3),an oval cystic mass,measuring approximately 10.0 cm × 10.0 cm × 10.0 cm,was visualized in the right anterior hepatic lobe,exhibiting characteristics consistent with hepatic unilocularE.granulosus.Moreover,an irregular solid mass,measuring about 5.0 cm × 5.0 cm × 5.0 cm,in the left outer lobe was identified,presenting features compatible with hepaticE.multilocularis.Lastly,dense adhesions connected both masses to the anterior abdominal wall,characteristic of hepatic multilocular Echinococcus larvae.

Figure 3 Intraoperative pathology specimens. A and B: Intraoperative visible lesions;C: Intraoperative excision of pathologic specimens (hepatic cystic echinococcosis and hepatic alveolar echinococcosis);D: Intraoperative excision of pathologic specimens (hepatic alveolar echinococcosis);E: Intraoperative excision of pathologic specimens (hepatic cystic echinococcosis);F: Intraoperative excision of pathologic specimens.Note: The white arrows indicate the site of the abdominal wall abscess sinus tract,and the blue arrows indicate the site of the hepatic alveolar echinococcosis lesion.

FINAL DIAGNOSIS

Based on these findings,the diagnosis was revised to mixed-type encapsulated hepatic echinococcosis (cystic and alveolar),with abdominal wall abscess and sinus tract formation.

TREATMENT

A combined multisegmental hepatectomy with abdominal wall sinus tract resection was performed.

OUTCOME AND FOLLOW-UP

Postoperatively,the patient was encouraged to wake up and eat early to promote organ function recovery[8].A follow-up CT scan 7 days postoperatively revealed a blurred fat space in the surgical area,with effusion,gas accumulation,and slight swelling of the right lower abdominal wall,with minimal exudate and pneumatosis;and unchanged scattered calcifications in the liver (Figure 2C).

Pathological examination of the liver hydatid tissue and fibrous cyst wall tissue revealed fibrous hyperplasia with hyalinization,necrosis,calcification,inflammatory cell infiltration,and minimal lamellar structures,consistent with echinococcosis (Figure 4).Nine days after surgery,the abdominal incision had healed well (Figure 1B),and the patient was discharged.

Figure 4 Postoperative pathology slides Histopathological examination by hemotoxylin-eosin staining (200 ×) fibrous connective tissue proliferation and inflammatory cell infiltration are seen around the blue arrow vesicles,forming nodules of varying sizes (alveolar echinococcosis) yellow arrow laminar-like structures are clearly visible (cystic echinococcosis).

Regular oral albendazole therapy was initiated,as per the 2019 diagnostic criteria and expert guidelines for hepatic echinococcosis.

DISCUSSION

While relying on the aforementioned criteria,this patient’s CT scan only revealed CE lesions and could not pinpoint the AE focus.Two factors might explain this.Initially,AE lesions often develop complete internal necrosis after infection,forming a thin and uniform abscess wall indistinguishable from CE on CT.Additionally,mixed CE and AE infections are uncommon and rarely appear clearly on scans.Even with CT,the optimal view for diagnosis is not always achieved,leading to potential bias in this report.

Surgical treatment for patients with combined CE and AE infections prioritizes surgical safety.Aim for radical surgery to remove all lesions comprehensively,while still employing individualized approaches for each patient.Postoperatively,all coinfected patients should adhere to the standard AE diagnosis and treatment regimen,involving ongoing benzimidazole therapy[8].

Echinococcosis primarily targets organs like the liver,lungs,and spleen,with abdominal wall invasion is highly unusual.This patient presented with a long-standing abdominal wall abscess and sinus tract,but had no other symptoms of discomfort.Despite no major liver vessel involvement,the complications were significant.For such cases,successful surgery hinges on radical resection of the abdominal wall abscess and sinus tract.Insufficient resection risks AE recurrence,while exceeding necessary bounds can compromise remaining liver volume and functionality,leaving a large abdominal wall defect.Therefore,surgeons must ensure a safe 1.0-cm resection margin while preserving enough normal abdominal tissue (transverse diameter <3 cm) and adequate blood supply[9,10].By adhering to these principles,supported by thorough preoperative evaluation,accurate surgical planning,and optimal postoperative care,our patient achieved complete recovery and was discharged without complications.

CONCLUSION

This report summarized our experience in diagnosing and treating this rare condition: A mixed infection of bothEchinococcusspecies with abdominal wall invasion and sinus tract formation.While the general treatment principles remain consistent with those of a simple infection by eitherE.granulosusorE.multilocularis,the presence of these additional complications necessitates additional considerations.For patients with long-standing lesions and established sinus tracts,radical resection of the affected tissue,including the sinus tracts and any abdominal wall abscesses,should be considered during surgery.This aligns with the principle of individualized treatment of echinococcosis.However,the long-term prognosis for such patients require postoperative albendazole treatment and regular follow-up protocols.

FOOTNOTES

Co-first authors:Miao-Miao Wang and Xiu-Qing An.

Co-corresponding authors:Ji-De A and Xiang-Ren A.

Author contributions:Wang MM,An XQ and Chai JP conceptualized and designed the research;Yang JY,A JD and A XR screened patients and acquired clinical data;Wang MM,An XQ and Chai JP collected blood specimen and performed laboratory analysis;Yang JY,A JD and A XR performed Data analysis;Wang MM,An XQ and Chai JP wrote the paper.All the authors have read and approved the final manuscript.Wang MM and An XQ prepared the first draft of the manuscript.Both authors have made crucial and indispensable contributions towards the completion of the project and thus qualified as the co-first authors of the paper.Both A JD and A XR have played important and indispensable roles in the experimental design,data interpretation and manuscript preparation as the co-corresponding authors.A XR conceptualized,designed,and supervised the whole process of the project.He searched the literature,revised and submitted the early version of the manuscript with the focus on the diagnosing and treating this rare condition: A mixed infection of bothEchinococcusspecies with abdominal wall invasion and sinus tract formation.This collaboration between A JD and A XR is crucial for the publication of this manuscript and other manuscripts still in preparation.

Supported byNational Natural Science Foundation of China,No.82260412.

Informed consent statement:This published consent was obtained from the patients or their representatives.

Conflict-of-interest statement:All the authors report no relevant conflicts of interest for this article.

CARE Checklist (2016) statement:The authors have read CARE Checklist (2016),and the manuscript was prepared and revised according to CARE Checklist (2016).

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Country/Territory of origin:China

ORCID number:Miao-Miao Wang 0009-0001-7601-4818;Xiu-Qing An 0009-0001-3161-0528;Jin-Ping Chai 0000-0001-8873-1323;Jin-Yu Yang 0000-0001-6376-9835;Ji-De A 0000-0003-4478-1972;Xiang-Ren A 0000-0002-0305-996X.

S-Editor:Li L

L-Editor:A

P-Editor:Cai YX