The significance of SREBP1 expression in HBV-related hepatocellular carcinoma

DENG Hui-zi, ZHENG Jing, WENG Yang, WEI Shang

Department of Pathology, the First Affiliated Hospital of Hainan Medical University, Haikou 570100, China

ARTICLE INFO

Article history:

Received 9 Feb 2023

Received in revised form 24 June 2023

Accepted 10 July 2023

Available online 14 Aug 2023

Keywords:

SREBP1

Hepatocellular carcinoma

HBV

De Novo Lipogenesis

ABSTRACTObjective:To investigate the relationship between SREBP1 protein expression and clinicopathological features of hepatitis B virus infection-related hepatocellular carcinoma.Methods:A total of 91 cases of hepatocellular carcinoma associated with hepatitis B virus infection and paired adjacent liver tissue samples were collected from the Department of Pathology, the First Affiliated Hospital of Hainan Medical College.The expression of SREBP1 protein in cancer and paired adjacent tissues was detected by immunohistochemical staining.The relationship between SREBP1 protein expression and clinicopathological features of hepatocellular carcinoma was analyzed by chi-square test.Results:The results of immunohistochemical staining showed that the ex- pression of SREBP1 protein in hepatocellular carcinoma was significantly higher than that in adjacent liver tissues(P<0.001).The expression level of SREBP1 protein was significantly correlated with tumor differentiation,distant metastasis or local recurrence in patients with hepatocellular carcinoma(P<0.05).The expression of SREBP1 protein was significantly up-regulated in the high HBV-related HCC virus load group (>103IU/mL) compared with the low HBV-related HCC virus load group(0～ 103IU/mL) (P<0.05).Conclusion: 1.The expression of SREBP1 protein is correlated with hepatocellular carcinoma, and shows a high expression trend, which provides direction and theoretical basis for the study of lipid metabolism regulation mechnism related to the occurrence and development of hepatocellular carcinoma.2.The expression of SREBP1 protein is correlated with the replication activity of hepatitis B virus,which provides a new research direction for the exploration of the mechanism of the occurrence and development of hepatitis B virus infection-related liver cancer.

?Corresponding author: ZHENG Jing, M.D., Associate Chief Physician.

E-mail: 443917583@qq.com.

Fund Project: Natural Science Foundation of Hainan Province (No.820RC763)