丙泊酚與七氟醚麻醉用于重癥顱腦外傷患者的效果

陳強(qiáng)

【摘要】目的：研究分析丙泊酚與七氟醚麻醉用于重癥顱腦外傷患者的效果。方法：本研究對(duì)我院于2019年5月—2021年5月期間收治的56例重癥顱腦外傷且行手術(shù)治療的患者資料進(jìn)行回顧性分析。依據(jù)其麻醉藥物使用不同分為七氟醚組和丙泊酚組，每組各28例患者。統(tǒng)計(jì)兩組患者在麻醉期間的不良反應(yīng)發(fā)生率、血清腦損傷標(biāo)志物、應(yīng)激反應(yīng)指標(biāo)及MMSE評(píng)分。結(jié)果：七氟醚組患者麻醉期間的不良反應(yīng)發(fā)生率明顯高于丙泊酚組患者，丙泊酚組的血清腦損傷標(biāo)志物、應(yīng)激反應(yīng)指標(biāo)及MMSE評(píng)分均優(yōu)于七氟醚組，效果相比存在明顯差異性（P<0.05）。結(jié)論：相較于七氟醚的麻醉效果，將丙泊酚應(yīng)用于重癥顱腦外傷患者的麻醉工作中能夠獲得更加理想的麻醉效果，且具有較高的安全性，具有較高的應(yīng)用價(jià)值，值得在臨床上進(jìn)行推廣應(yīng)用。

【關(guān)鍵詞】丙泊酚；七氟醚；重癥顱腦外傷；麻醉效果

Effect of propofol and sevoflurane anesthesia on patients with severe craniocerebral trauma

CHEN Qiang

Hunan Aerospace Hospital， Changsha， Hunan 410205， China

【Abstract】Objective： To study and analyze the effect of propofol and sevoflurane anesthesia in patients with severe craniocerebral trauma.Methods： The data of 56 patients with severe craniocerebral trauma who received surgical treatment in our hospital from May 2019 to May 2021 were retrospectively analyzed. They were divided into the sevoflurane group and the propofol group according to the different use of anesthetic drugs，with 28 patients in each group.The incidence of adverse reactions，serum markers of brain injury，stress response indexes and MMSE scores of the two groups during anesthesia were counted.Results： The incidence of adverse reactions during anesthesia in the sevoflurane group was significantly higher than that in the propofol group，the serum markers of brain injury，stress response index and MMSE score in the propofol group were better than those in the sevoflurane group，and there were significant differences in efficacy（P<0.05）.Conclusion： Compared with the anesthetic effect of sevoflurane，the application of propofol in the anesthesia of patients with severe craniocerebral trauma can obtain more ideal anesthetic effect，with higher safety and higher application value，which is worthy of clinical promotion and application.

【Key Words】Propofol； Sevoflurane； Severe craniocerebral trauma； Effect of anesthesia

重癥顱腦外傷屬于神經(jīng)外科在臨床上十分高發(fā)的危重癥，該疾病發(fā)展速度快，且患者病情危重，致殘率和死亡率極高，嚴(yán)重威脅到患者的生命安全[1]。現(xiàn)階段臨床上主要采取手術(shù)方法對(duì)該類患者進(jìn)行治療，雖然能夠獲得一定的效果，但該類患者在術(shù)中十分容易發(fā)生缺氧性損傷、繼發(fā)缺血等情況，從而會(huì)對(duì)整體治療和預(yù)后效果造成影響[2]。因此，在手術(shù)麻醉時(shí)需要通過安全、有效的措施保護(hù)患者的腦細(xì)胞功能，降低其各類并發(fā)癥的發(fā)生率，確保患者的神經(jīng)功能不會(huì)受到破壞[3]。在此基礎(chǔ)上，本研究對(duì)我院于2019年5月—2021年5月期間內(nèi)收治的重癥顱腦外傷患者的資料進(jìn)行回顧性研究，分析其接受丙泊酚與七氟醚麻醉的效果，現(xiàn)以下文進(jìn)行詳細(xì)報(bào)道。……