Clinical efficacy of external treatment with Zi Cao Yang He Tang combined with hormone therapy for granulomatous mastitis and its effect on cellular pyroptosis proteins

MU Yu-jing, WANG Tang-shun, FENG Xue, SUN Ping, GAO Shuang, WANG Yu-kun,ZUO Xi-meng, ZHU Yan-yan, MA Yan, SHI Xiao-guang

Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing 100007, China

ARTICLE INFO

Article history:

Received 23 May 2023

Received in revised form 29 August 2023

Accepted 16 Oct 2023

Available online 28 Nov 2023

Keywords:

Zi Cao Yang He Tang

Granulomatous lobular mastitis

Traditional Chinese medicine

External treatment

Glucocorticoid

ABSTRACTObjective:To observe the clinical effect of external application of Zi Cao Yang He Tang combined with dexamethasone ointment in the treatment of granulomatous lobular mastitis in the mass stage and the effect on cellular pyroptosis-related proteins.Methods:Forty patients with granulomatous lobular mastitis were randomly divided into 20 cases in the observation group and 20 cases in the control group.Both groups were given dexamethasone ointment for treatment, and the observation group was treated with external application of Zi Cao Yang He Tang on the basis of the control group.Breast lump vol-ume changes, breast pain and pus symptoms, pathology and histology and immunohistochemistry, cellular death-related indicators expression were compared between the two groups.Results:After treatment, the difference in mass volume of the observation group was significantly greater than that of the control group(16.7±21.5 in the control group and 32.9±27.4 in the experimental group)and the difference between the two groups was statistically significant(P<0.05);the objective remission rate of the patients in the observation group(ORR=85%)was significantly higher than that of the treatment group(ORR=50%, P<0.05).In terms of pus formation rate and pain level, the breast pain score of the observation group was significantly lower than that of the control group after two weeks or three weeks of treatment(P<0.05); the pus formation rate of the observation group was 30%, and the pus formation rate of the control group was 20%, and the difference was not statistically significant(P>0.05).The immunohistochemical expression levels of caspase-1 and GSDMD in the observation group were significantly lower than those in the control group(P<0.05); and in terms of the expression of cellular pyroptosis-related indexes, the expression of GSDMD, cas-pase-1,and NLRP3 in the observation group was significantly lower compared with that in the control group(P<0.05).Conclusion:The efficacy of external application of Zi Cao Yang He Tang combined with dexamethasone ointment in treating granulomatous lobular mastitis in the mass stage is remarkable, which can effectively reduce breast pain, reduce the size of the mass, de-crease the expression of cellular pyroptosisrelated indexes,and have a good anti-inflammatory effect.

?Corresponding author: FENG Xue,M.M.,Attending Physician.

E-mail: 943752868@qq.com.

Fund Project: Hubei Chen Xiaoping Science and Technology Development Foundation Special Fund Project (No.CXPJJH12000002-2020010); Education Science Research Project,Beijing University of Chinese Medicine (No.XJY21056);Beijing University of Chinese Medicine New Teachers Start-up Fund Project(No.2022-BUCMXJKY010)