Different nutrient compositions in diet and taking hypoglycemic drugs can modulate gut microbial flora

TO THE EDITOR

Diabetes mellitus (DM) is one of important risk factor for population health in the twenty-first century worldwide. It is of great significance to explore the lifestyle intervention mode for the prevention and treatment of type 2 diabetes mellitus (T2DM). One study found intermittent hypoxia (IH) was associated with metabolic diseases including as obesity and obstructive sleep apnea-hypopnea syndrome (OSAHS)[1]. IH may be involved in selective alterations of the gut microbiota of T2DM patients with OSAHS. Similarly, changes in gut microbiota can affect the development of T2DM.

Gut microbiota is known to change with diet. Especially when someone suffering from T2DM,doctors often recommend dietary changes to curb the progression of the disease. Changes in eating habits can disrupt the balance of gut microbiota when the body's resistance is low[2]. The study by Liu

[3] showed that blood sugar levels in mouse model of T2DM induced by streptozotocin-high-fat diet were changes with gut microbiota. A large number of studies have shown that diet affects the development of diabetes. For example, blackcurrant extract enhanced insulin sensitivity and glucosestimulated insulin secretion in non-obese type 2 diabetic rats[4]. Therefore, the diet structure will affect the gut microbiota. However, the following questions need to be further clarified in future studies. What nutrition considerations for persons with diabetes that will impact persons? What are the recommendations for persons with diabetes concerning nutrition to be considered? The link between gut microbial,diabetes, nutrition and autoimmunity are important, but still need to be addressed.

In addition, hypoglycemic drugs also affect gut microbiota. In this study, drugs that regulate IH have an effect on the balance of gut microbiota. We strongly agree with this view. However, when taking drugs to regulate IH, hypoglycemic drugs are also used. Therefore, hypoglycemic drugs also have an impact on the balance of gut microbiota. For some patients who require combination therapy to treat diabetes and complications of diabetes, especially after combination therapy with antibiotics and hypoglycemic drugs, the impact on the intestinal flora is significant[5]. Clinically, metformin is widely used in the treatment of T2DM. Studies have shown that gut microbiota is an active site of metformin.The gut is a potential target of metformin. Metformin induce butyrate and propionate involving glucose homeostasis[6]. When diabetics take metformin, the gut microbiota will definitely change. Studies have also shown that treating diabetic mice with oleuropein (OP) is also treated by modulating the gut microbiota. The OP could decrease fasting blood glucose levels and improve glucose tolerance[7].Hypoglycemic drugs are also taken when taking drugs that regulate IH, so hypoglycemic drugs will also affect the intestinal flora of patients with IH. It is common for IH patients to take hypoglycemic drugs, so the regulation of hypoglycemic drugs on gut microbiota also needs to be discussed.

On the other hand, IH may be associated with changes in gut microbiota, and it is possible that changes in gut microbiota led to IH. In the clinical setting, the effective treatment for IH is usually oxygen therapy. Thus, we can use oxygen inhalation to intervene in changes in gut microbiota. By conducting oxygen supply experiments, the relationship between IH and gut microbiota can be further reflected, which makes the research results more convincing.

The diet structure of diabetic patients is different from that of normal people. Diabetic patients also need to take hypoglycemic drugs to regulate blood sugar. Both dietary structure of patients with diabetes and hypoglycemic drugs taken by the patients with diabetes can alter the gut microbiota of the patients. Therefore, the influence of diet and drugs on the gut microbiota cannot be ignored.

FOOTNOTES

China

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Fan JR

All the authors report no relevant conflicts of interest for this article.

He LP and Liu CW contributed to the conception of research; Zhang QW, Lin ZJ and Zhou B wrote the manuscript; Zhang QW, Lin ZJ and Yu XL contributed to the revision of the manuscript.

Zi-Jun Lin 0000-0003-1478-3440; Qiong-Wen Zhang 0000-0002-4811-1821; Xiao-Lan Yu 0000-0003-0503-8940; Bo Zhou 0000-0002-2141-4523; Chang-Wei Liu 0000-0002-7590-5176; Lian-Ping He 0000-0002-9627-5599.

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