康艾注射液聯(lián)合紫杉醇和順鉑化療方案治療晚期卵巢癌的臨床效果及不良反應

朱風婷　姜靖雯　張慧

摘要目的：分析康艾注射液聯(lián)合紫杉醇和順鉑化療方案（TP）治療晚期卵巢癌的臨床效果及不良反應。方法：選取2017年1月至2019年1月海南省中醫(yī)院收治的晚期卵巢癌患者166例作為研究對象，按照隨機數(shù)字表法分為對照組和觀察組2組，每組83例。對照組患者以TP治療，觀察組患者在TP基礎上接受康艾注射液治療。分析2組患者的臨床效果及治療后的不良反應。結果：與對照組比較，觀察組治療后腫瘤控制總有效率及腹腔積液控制總有效率明顯升高（P<0.05）;與對照組比較，觀察組治療后KPS評分提高率及穩(wěn)定率明顯高于對照組（P<0.05）。2組患者治療后CD3+、CD4+和CD4+/CD8+明顯降低，差異均有統(tǒng)計學意義（均P<0.05），而CD8+明顯升高，但差異無統(tǒng)計學意義（P>0.05）。觀察組治療后血白細胞、血紅蛋白、中性粒細胞絕對值及淋巴細胞絕對值均明顯升高，治療前后比較，差異均有統(tǒng)計學意義（均P<0.05），而對照組治療前后上述指標無明顯變化（P>0.05）。結論：康艾注射液聯(lián)合TP治療晚期卵巢癌臨床效果確定但未引起明顯的不良反應。

關鍵詞康艾注射液;紫杉醇和順鉑化療方案;晚期卵巢癌;不良反應;白細胞數(shù);血紅蛋白

Effect and Toxicity of Kang′ai Injection Combined with TP Regimen in the Treatment of Advanced Ovarian Cancer

ZHU Fengting，JIANG Jingwen，ZHANG Hui

（Department of Oncology，Hainan Provincial Hospital of Traditional Chinese Medicine

Oncology of Traditional Chinese Medicine，Haikou 570203，China）

AbstractObjective：To study the efficacy and side effects of Kang′ai injection combined with TP chemotherapy in the treatment of advanced ovarian cancer.Methods：Patients with advanced ovarian cancer admitted to Hainan Provincial Hospital of Traditional Chinese Medicine from January，2017 to January，2019 were studied.All 166 patients were randomly divided into two groups：a control group（n=83） and an observation group（n=83）.The patients in the control group received TP chemotherapy treatment.The patients in the observation group received Kang′ai injection on the basis of TP chemotherapy.The clinical effect and side effects of the two groups were analyzed.Results：Compared with the control group，the total effective rate of tumor control and peritoneal effusion control in the observation group increased significantly after treatment（P<0.05）.The improvement rate and stability rate of KPS score in the observation group after treatment were significantly higher than those in the control group（P<0.05）.After treatment，CD3+，CD4+ and CD4+/CD8+ in both groups were significantly decreased（P<0.05），while CD8+ was increased with no statistical difference（P>0.05）.The absolute value of leukocyte，hemoglobin，neutrophil and lymphocyte in the observation group increased significantly（P<0.05）.There was no significant change in the above indexes before and after treatment in the control group（P>0.05）.Conclusion：Kang′ai injection combined with TP chemotherapy has obvious clinical effect on patients with advanced ovarian cancer，but it does not cause obvious side effects.

KeywordsKang′ai injection; TP chemotherapy; Advanced ovarian cancer; Side effects; Leukocyte number; Hemoglobin

中圖分類號：R273文獻標識碼：Adoi：10.3969/j.issn.1673-7202.2022.04.016

卵巢癌是臨床上女性生殖系統(tǒng)中最常見的惡性腫瘤之一，嚴重威脅患者的健康[1]。卵巢癌患者早期無明顯的臨床表現(xiàn)，臨床確診時通常處于中晚期，預后差[2]。化療在腫瘤的治療中發(fā)揮著越來越重要的作用，但其容易引起一系列的不良反應，如胃腸道反應、重要器官功能的破壞以及骨髓抑制等[34]。……