普瑞巴林與綜合康復(fù)對急性重度神經(jīng)根型頸椎病的療效

倪小紅 蔡煒瓊 徐娟娟 王榮 詹浩東 呂衍文

摘 要 目的：探討普瑞巴林與綜合康復(fù)對急性重度神經(jīng)根型頸椎病的臨床療效。方法：選取120例急性重度神經(jīng)根型頸椎病患者，采用隨機(jī)數(shù)字表法分為觀察組和對照組各60例，對照組實施綜合康復(fù)治療，觀察組在對照組的基礎(chǔ)上給予普瑞巴林治療。觀察兩組治療前后的VAS評分、頸椎病治療成績評分和HAMA評分、PSQI評分。結(jié)果：觀察組治療5、7、12 d后VAS評分低于對照組；治療14 d后頸椎病治療成績評分高于對照組，HAMA評分和PSQI評分低于對照組（P<0.05）。結(jié)論：急性重度神經(jīng)根型頸椎病采用普瑞巴林和綜合康復(fù)治療的療效較好，對于改善患者頸椎功能、緩解不良情緒有著積極的促進(jìn)作用，提高了患者的睡眠質(zhì)量和生活質(zhì)量。

關(guān)鍵詞 急性重度神經(jīng)根型頸椎病 綜合康復(fù) 普瑞巴林

中圖分類號：R971.6； R681.55 文獻(xiàn)標(biāo)志碼：A 文章編號：1006-1533（2021）19-0021-03

Efficacy of pregabalin and comprehensive rehabilitation in patients with acute severe nerve root cervical spondylopathy

NI Xiaohong1， CAI Weiqiong2， XU Juanjuan3， WANG Rong4， ZHAN Haodong5， LYU Yanwen6（1. Department of Rehabilitation Medicine， 3. Department of Cardiology， 4. Department of Burns and Plastic Surgery， 5. Cardiothoracic Surgery Room， 6. Department of Neurology， Huanggang Central Hospital， Huanggang 438000， China； 2. Department of Ultrasound， Maternal and Child Health Hospital of Huanggang City， Huanggang 438000， China）

ABSTRACT Objective： To analyze the clinical efficacy of pregabalin and comprehensive rehabilitation in patients with acute severe cervical spondylosis. Methods： A total of 120 patients with acute severe radiculopathy of cervical spondylosis were selected and divided into an observation group and a control group with 60 cases each based on a random number table method. The control group was given comprehensive rehabilitation treatment while the observation group was treated with pregabalin plus comprehensive rehabilitation. The VAS scores， the cervical spondylosis treatment scores， HAMA scores and PSQI scores in the two groups were observed before and after treatment. Results： The VAS scores at 5， 7 and 12 days after treatment was significantly lower in the observation group than the control group， the cervical spondylosis treatment scores were significantly higher and the HAMA scores and PSQI scores were significantly lower in the observation group than the control group 14 days after treatment （P<0.05）. Conclusion： Pregabalin and comprehensive rehabilitation have a significant effect and in the treatment of patients with acute severe cervical spondylosis and a positive promoting effect on improving the cervical spine function and relieving bad mood of the patients and can improve the quality of sleep and life of the patients.

KEy wORDS acute severe nerve root type cervical spondylosis； comprehensive rehabilitation； pregabalin

老年人是頸椎病的多發(fā)群體，近年來逐漸年輕化，此外睡眠體位不佳者和長期坐姿不端正者也易患頸椎病[1]。頸椎病又被稱之為頸椎綜合征，其引發(fā)的原因是由于頸椎長期受損、骨質(zhì)增生或腰椎間盤突出等。患者常見癥狀表現(xiàn)為：手指發(fā)麻、下肢無力和頸背疼痛等[2]。在頸椎病中，神經(jīng)根型頸椎病尤為多發(fā)，急性重度神經(jīng)根型頸椎病患者主要呈現(xiàn)出上肢局部麻木，頸椎活動范圍受限等，對于患者的日常生活和工作具有極大影響[3]。目前，治療重度神經(jīng)根型頸椎病的方式多樣，多以保守常規(guī)治療為主，但其緩解疼痛等效果并不明顯。