鹽酸帕羅西汀結合小劑量非典型抗精神病藥物在老年抑郁癥患者中的應用價值

劉玉紅

[關鍵詞] 抗精神病藥;帕羅西汀;老年抑郁癥;不良反應;生存質量;奧氮平

[中圖分類號] R749.41? ? ? ? ? [文獻標識碼] B? ? ? ? ? [文章編號] 1673-9701（2021）21-0030-04

Application value of paroxetine acid combined with low-dose atypical antipsychotics in elderly patients with depression

LIU Yuhong

Department of Psychiatry， Inner Mongolia Mental Health Center， Inner Mongolia Hohhot，? ?010010， China

[Abstract] Objective To investigate the effect of paroxetine hydrochloride combined with low-dose atypical antipsychotics in the treatment of elderly patients with depression. Methods Ninety-two elderly patients with depression treated in our hospital from January 2019 to December 2019 were selected. They were divided into the control group and the experimental group using the random number table method， with 46 patients in each group. The control group were treated with paroxetine， and the experimental group were treated with paroxetine combined with low-dose atypical antipsychotics （olanzapine）. The differences in the total effective rate， quality of life scale （HOQOL-BREF） score， anxiety self-rating scale （SAS） score， Hamilton depression scale （HAMD-17） score and adverse event scale score were compared between the two groups after 8 weeks of treatment. Results The total effective rate of patients in the experimental group （100.00%） was higher than that in the control group （73.91%）， with statistically significant difference （P<0.05）. There were no statistically significant differences in the HOQOL-BREF score， SAS score， and HAMD-17 score between the two groups before treatment （P>0.05）. There were no statistically significant differences in the HOQOL-BREF score， SAS score and HAMD-17 score between the two groups after treatment （P<0.05）. There was no statistically significant difference in the adverse event scale score between the two groups （P>0.05）. Conclusion Paroxetine combined with olanzapine can be considered as the treatment for elderly patients with depression. It can effectively improve the quality of life of patients and is worthy of application.

[Key words] Antipsychotics; Paroxetine; Elderly depression; Adverse event; Quality of life; Olanzapine

抑郁癥屬于臨床上常見的一種心理障礙疾病，其病因復雜多樣，主要表現為情緒低落、失眠多夢甚至絕望自殺，具有較高的發病率[1]。隨著近年來社會不斷發展，在日常工作和生活中人們面臨的壓力越來越大，使得抑郁癥在我國的發病率不斷上升[2]。此外，我國正在逐步進入老齡化社會，導致老年人口有所增加，老年抑郁癥發生率也呈上升趨勢，通常老年患者的抑郁癥狀不典型，病程較長，很容易發展為慢性病[3]。目前，藥物干預是臨床治療抑郁癥的主要手段之一，可以有效緩解患者的不良心理情緒，改善抑郁行為，提高生活質量[4]。帕羅西汀是目前精神科比較常用的新型抗抑郁劑，臨床上應用較多[5]。近些年來，非典型抗精神病藥物已逐漸作為首選藥物廣泛應用于各類精神疾病的治療，尤其是用于初發病患者，其中又以奧氮平最受歡迎，奧氮平主要用于治療精神分裂癥[6]。因此，選取研究病例為我院老年抑郁癥患者，將上述藥物應用其中，現報道如下。