硫酸鎂聯合拉貝洛爾治療妊娠高血壓的療效及對妊娠結局的影響

相婧婧

[關鍵詞] 硫酸鎂;拉貝洛爾;妊娠高血壓;妊娠結局

[中圖分類號] R714.2? ? ? ? ? [文獻標識碼] B? ? ? ? ? [文章編號] 1673-9701（2021）19-0082-03

Efficacy of magnesium sulfate combined with labetalol in the treatment of pregnancy-induced hypertension and its influence on pregnancy outcome

XIANG Jingjing

Department of Obstetrics and Gynecology， Shuyang Hospital Affiliated to Xuzhou Medical University（Shuyang People′s Hospital）， Shuyang 223600， China

[Abstract] Objective To explore the therapeutic effect of magnesium sulfate combined with labetalol and its influence on pregnancy outcome in patients with pregnancy-induced hypertension. Methods A total of 56 patients with pregnancy-induced hypertension admitted to our hospital from January 2018 to December 2019 were randomLy divided into the observation group （28 cases treated with magnesium sulfate combined with labetalol） and the control group （28 cases treated with magnesium sulfate treatment）. The clinical efficacy and maternal and infant outcome after treatment was observed. Results The systolic blood pressure of the observation group was （135.61±6.24）mmHg， lower than the control group′s （142.62±8.75）mmHg.The diastolic blood pressure of the observation group was （86.63±4.19）mmHg，lower than the control group′s （92.47±5.86）mmHg. The total effective rate of treatment was The total effective rate of treatment in the observation group was 92.86%， which was significantly higher than 67.86% in the control group. The incidence of cesarean section， premature delivery， and postpartum hemorrhage of the observation group were 17.86%， 7.14%， and 10.71%， which were lower than those （50.00%， 35.71%， and 38.28%） of the control group. The incidence of fetal asphyxia and intrauterine distress of the observation group was 0.00% and 7.14%， respectively，lower than those （21.43% and 32.14%） of the control group， and the difference was statistically significant（P<0.05）.There was no significant difference in the incidence of fetal death between the two groups（P>0.05）. Conclusion Magnesium sulfate combined with labetalol can effectively control the blood pressure of patients with pregnancy-induced hypertension， improve the total effective rate of clinical treatment， and improve the maternal and infant outcome.

[Key words] Magnesium sulfate; Labetalol; Regnancy-induced hypertension; Pregnancy outcome

妊娠高血壓是妊娠期婦女常見的并發癥之一，在妊娠20周后發生率較高，約為10%，與孕婦年齡、所處環境、疾病史、營養狀況及精神狀態關系密切[1-2]。臨床常表現為頭暈、頭痛、血壓升高、惡心嘔吐、蛋白尿及水腫等，嚴重時會引發抽搐、昏迷等惡性癥狀，易發生早產、剖宮產、產后出血及胎兒宮內窘迫、窒息等不良妊娠結局，進而威脅母嬰生命安全[3]。妊娠高血壓患者因其處于特殊階段，治療需多方面考慮及綜合評估[4]。硫酸鎂是臨床治療妊娠高血壓的常用藥物，其作用主要是增加鎂離子含量，拮抗鎂離子釋放及阻滯神經傳導、松弛骨骼肌及鎮靜作用[5]。但單一用藥效果相對局限，用量過多甚至會引發鎂離子中毒，影響預后結局，所以需采取其他藥物聯合治療[6]。本研究探討硫酸鎂聯合拉貝洛爾治療妊娠高血壓的臨床效果，現報道如下。