Lung cancer from a focal bulla into thin-walled adenocarcinoma with ground glass opacity — an observation for more than 10 years: A case report

Shu-Shi Meng, Shao-Dong Wang, Yuan-Yuan Zhang, Jun Wang

Shu-Shi Meng, Shao-Dong Wang, Jun Wang, Department of Thoracic Surgery, Peking University People’s Hospital, Beijing 100044, China

Yuan-Yuan Zhang, Department of Pathology, Peking University People’s Hospital, Beijing 100044, China

Abstract

Key words: Thin-walled lung cancer; Observation; The check-valve mechanism; Case report

INTRODUCTION

Lung cancer has one of the highest mortality rates worldwide. Low-dose computed tomography (CT) has become an important method for screening and monitoring recurrence in lung cancer[1]. The manifestations of lung cancer on CT imaging are diverse. Solitary thin-walled lung adenocarcinoma is a special form of lung cancer,which is rare in clinical practice[2]. Its pathogenesis is inconclusive and diagnosis is very challenging. It is often misdiagnosed as a benign lesion such as a pulmonary cyst or tuberculous cavity, thus delaying diagnosis and surgical treatment[3]. We describe a rare case of lung adenocarcinoma with gradual enlargement of a thin-walled cavity surrounded by pure ground glass opacity (GGO) on CT for more than 10 years.

CASE PRESENTATION

Chief complaints

A 66-year-old male patient presented with a thin-walled cavity surrounded by a GGO in the right lung on CT in November 2017. The patient had no obvious discomfort.

History of present illness

A previous chest CT in 2007 showed a 4.3 cm × 2.5 cm mass in the right upper lobe and a small thin-walled cavity in the right anterior basal segment (Figure 1). The patient underwent video-assisted thoracoscopic lobectomy for primary lung adenocarcinoma in the right upper lobe in August 2007, and pathology demonstrated a well differentiated adenocarcinoma of stage T2bN0M0 (stage 2A). The small thinwalled cavity was considered benign and was not treated. During his regular followup, no obvious change was observed in 2008, while the cavity gradually enlarged from 11 mm to 14 mm in diameter and no recurrence was observed on the chest CT from 2008 to 2014. During the next two years, the patient did not undergo any examinations and paid no attention to the cavity. In August 2017, his chest CT scan showed that the size of the lesion had increased to 31 mm and had become a bulla surrounded by GGO (Figure 2).

History of past illness

The patient was in good health with no comorbidities, except for a history of lung cancer surgery in 2007 (adenocarcinoma in the right upper lobe, at T2bN0M0 stage 2A).

Personal and family history

The patient had a 40 pack-year history of cigarette smoking and a history of contact with tuberculosis patients, including his mother and sister.

Physical examination upon admission

His vital signs were stable, and no obvious abnormalities were found on examination.

Laboratory examinations

Related tumor markers were negative.

Figure 1 Chest computed tomography scan in 2007 showed a 43-mm solid lesion in the right upper lung and a small thin-walled cavity in the lower lobe. A: A 43-mm solid lesion in the right upper lung; B: A small thin-walled cavity in the lower lobe (arrow).

Imaging examinations

We traced the CT data of this patient for 10 years. As mentioned earlier, the small thin-walled cavity gradually transformed into GGO around the bulla. On the enhanced CT scanning, the degree of enhancement of the lesion was difficult to evaluate, and the structure inside the cavity was irregular. Imaging physicians and lung cancer surgeons believed that the lesion was highly malignant, based on its imaging characteristics and the process of evolution in recent years.

FINAL DIAGNOSIS

Final postoperative pathology diagnosis was lepidic predominant adenocarcinoma.

TREATMENT

The patient underwent video-assisted thoracoscopic wedge resection of the right lower lobe on November 15, 2017. The surgical specimen showed a cavity with a malignant appearance in the surrounding tissue (Figure 3). The pathological result was lepidic predominant adenocarcinoma (Figure 4). No lymph node metastasis was observed and no further treatment was required after surgery.

OUTCOME AND FOLLOW-UP

The patient recovered well and was discharged one week after surgery. During the follow-up period of 24 mo, no recurrence was noted.

Figure 2 Serial computed tomography images over 10 years in this patientshowed the gradual evolution of an 11-mm right lower lobe thin-walled cystic airspace (A, arrow) into a 31-mm cystic airspace with a thick wall demonstrating as a GGO (F, arrow). A: Before the first operation (2007); B: Three years later;C: 4.4 years later; D: 5.8 years later; E: 7 years later; F: 10 years later.

DISCUSSION

Lung cancer presenting as cystic lesions was first described by Anderson and Pierce in 1954[4]. A recent study suggested that the incidence of cystic lung cancer was 0.46% of surgical cases (15 of 3268)[5]. Histological analysis showed that most cases were adenocarcinoma. It is suggested that malignant imaging features often include asymmetric thickening of the wall, septum in the cavity, irregular margin, short spicules, and blood vessel convergence signs. Due to the thin walls, ordinary percutaneous needle biopsy and transbronchial biopsy rarely obtain sufficient diagnostic specimens. It is reported that the sensitivity of CT-guided percutaneous needle aspiration in these cases is 91%[5].

The pathogenesis of bullous lung cancer remains unclear. There are several hypotheses on the tumorigenesis: The check-valve mechanism; central necrosis and enzymatic digestion of solid lesions; lesions invading the original cyst structure,etc. It has been reported that the check-valve is formed as a result of bronchial wall collapse,which leads to the cavity, and as the internal pressure increases, the cavity gradually increases, and the irregular growth of the tumor tissue forms asymmetric thickening of the wall[6].

Figure 3 Surgical specimen showing a thick-walled cavity (arrow) with a malignant appearance in the surrounding tissue.

In the present case, the patient’s imaging data showed clearly the enlargement of the thin-walled lung adenocarcinoma. CT images 10 years previously did not provide sufficient evidence of malignancy. Without continuous observation over 10 years, this lesion may have been regarded as a tuberculous cavity or local inflammation. By analyzing the evolution of the lesion, an accurate diagnosis can be established and appropriate treatment provided. It can also enhance the surgeon’s awareness of this disease, and add experience of diagnosis and treatment. Observation and follow-up of suspicious lesions contribute to appropriate clinical decisions.

Previously reported cases of lung cancer presenting as thin-walled cysts had a maximum observation time of 6 mo[5]. Very few patients with multiple primary cancers have been reported. Lung adenocarcinoma with gradual enlargement of a thin-walled cavity surrounded by pure GGO for more than 10 years has never been reported before. We report the natural course of lung adenocarcinoma with a thinwalled cavity, which confirms the check-valve mechanism.

CONCLUSION

Solitary thin-walled lung adenocarcinoma is a rare tumor in terms of its clinical manifestations, pathogenesis, and disease progression. The check-valve mechanism explains the cause of thin-walled lung cancer. Due to the difficulty in diagnosing this disease, close follow-up and accurate imaging are required.

Figure 4 Histologic image (hematoxylin and eosin stain, × 2) demonstrating a part of the bulla (asterisk) and lepidic growth of adenocarcinoma (arrows).

ACKNOWLEDGEMENTS

The authors appreciate the efforts of the surgeons, and doctors and nurses from pathology, radiology, and anesthesia departments in this case report.