HMGB1、MMP-9及VEGF-C在老年肺癌患者組織中水平變化及意義研究

孫黨澤 張濰

[摘要] 目的 探討HMGB1、MMP-9及VEGF-C在老年肺癌患者組織中的水平變化及意義。方法 方便選取2018年1月—2019年3月該院收治的60例老年肺癌患者和36例癌旁組織（距肺癌病灶2 cm）標本作為研究對象，比較兩組患者HMGB1、MMP-9、VEGF-C陽性表達情況，并探討肺癌組織中HMGB1、MMP-9及VEGF-C表達與臨床病理特征的關系。結果 肺癌組患者HMGB1、MMP-9及VEGF-C陽性表達率（63.3%、70.0%、66.7%）顯著高于癌旁組（31.4%、28.6%、0.0%），差異有統計學意義（χ2=13.046、9.259、5.392，P<0.05）;肺癌組織中HMGB1、MMP-9、VEGF-C表達與性別、年齡、分化程度無關，差異無統計學意義（P>0.05）;腺癌、有淋巴結轉移的HMGB1、MMP-9、VEGF-C陽性表達率（76.5%、79.4%、82.4%;85.7%、89.3%、82.1%）顯著高于鱗癌、無淋巴結轉移（50.0%、26.9%、50.0%;46.9%、56.3%、53.1%），差異有統計學意義（χ2=7.126、5.336、4.825、10.392、3.503、5.177，P<0.05）。 結論 肺癌組患者HMGB1、MMP-9及VEGF-C陽性表達率均顯著高于癌旁組，肺癌組織中HMGB1、MMP-9、VEGF-C陽性表達與組織學分型和無淋巴結轉移有關。

[關鍵詞] 肺癌; 高遷移率族蛋白B1; 基質金屬蛋白酶-9; 血管內皮生長因子-C

[Abstract] Objective To investigate the changes and significance of HMGB1， MMP-9 and vascular endothelial growth factor-C in elderly patients with lung cancer. Methods From January 2018 to March 2019， 60 elderly patients with lung cancer and 36 adjacent tissues （2 cm away from the lesion of lung cancer） were convenient selected as the study subjects. The positive expression of HMGB1， MMP-9 and VEGF-C in the two groups were compared， and the relationship between the expression of HMGB1， MMP-9 and VEGF-C in lung cancer tissues and clinicopathological characteristics was discussed. Results The positive expression rates of HMGB1， MMP-9 and VEGF-C in lung cancer group （63.3%， 70.0%， 66.7%） were significantly higher than those in para-cancer group （31.4%， 28.6%， 0.0%），the difference was statistically significant（χ2=13.046， 9.259， 5.392， P<0.05）; the expressions of HMGB1， MMP-9 and VEGF-C in lung cancer tissues were not related to sex， age and differentiation degree，the difference was notstatistically significant （P>0.05）; the positive expression rates of HMGB1， MMP-9 and VEGF-C in adenocarcinoma， lymph node metastasis （76.5%， 79.4%， 82.4%; 85.7%， 89.3%， 82.1%） were significantly higher than those of squamous cell carcinoma and non-lymph node metastasis （50.0%， 26.9%， 50.0%; 46.9%， 56.3%， 53.1%），the difference was statistically significant（χ2=7.126， 5.336， 4.825， 10.392， 3.503， 5.177， P<0.05）. Conclusion The positive expression rates of HMGB1， MMP-9 and VEGF-C in lung cancer group were significantly higher than those in adjacent group. The positive expression rates of HMGB1， MMP-9 and VEGF-C in lung cancer tissue were related to histological classification and lymph node metastasis.

[Key words] Lung cancer; High mobility group protein B1; Matrix metalloproteinase-9; Vascular endothelial growth factor-C