Sigmoid colon duplication with ectopic immature renal tissue in an adult: A case report

Hwan Namgung

Hwan Namgung, Department of Surgery, Dankook University College of Medicine, Cheonan 31116, South Korea

Abstract BACKGROUND Colonic duplication is a rare congenital anomaly. Many types of heterotopic tissue were identified within the wall of duplication. However, studies of ectopic immature renal tissue (EIRT) involving colon duplication in an adult have yet to be reported.CASE SUMMARY A 23-year-old woman visited our hospital with symptoms of recurrent abdominal pain and chronic constipation. Image analysis via abdomino-pelvic computed tomography, Gastrografin contrast study, and colonoscopy showed a blind and dilated bowel loop filled with fecal material located on the mesenteric side of the sigmoid colon. We established a diagnosis of sigmoid colon duplication and decided to perform a laparoscopic investigation. Segmental resection of the sigmoid colon with duplication was done. Microscopically, the duplicated segment showed all three layers of the bowel wall and EIRT in the wall of the duplication. The postoperative period was uneventful and the patient was discharged nine days after the surgery without complications. She has been doing well 12 mo after the follow-up period.CONCLUSION A comprehensive histopathologic examination for ectopic tissues or tumors is mandatory after resection of colon duplication.

Key Words: Colon duplication; Ectopic immature renal tissue; Case report

INTRODUCTION

Several studies have reported different types of heterotopic tissue within duplications.The common types of ectopic tissue include gastric mucosal, squamous, and pancreatic tissues[1]. Ectopic immature renal tissue (EIRT) is a metanephric remnant arrested in an extra-renal site due to abnormal migration[2]. We report a case of sigmoid colon duplication with EIRT. To our knowledge, this is the first report of EIRT occurring within the wall of a colonic duplication in an adult.

CASE PRESENTATION

Chief complaints

A 23-year-old woman visited our hospital with symptoms of recurrent abdominal pain and chronic constipation.

History of present illness

The patient’s history reveals multiple hospitalizations during childhood for similar symptoms without a clear diagnosis.

History of past illness

The patient had a free previous medical history.

Personal and family history

No personal and family history was identified.

Physical examination

The physical examination was unremarkable except for tenderness in the right lower quadrant.

Laboratory examinations

All laboratory tests were in the normal range.

Imaging examinations

Abdomino-pelvic computed tomography (CT) showed a blind, dilated bowel loop filled with fecal material, directed to the right upper quadrant (RUQ) of the abdomen.This bowel loop communicated with the sigmoid colon and was located on the mesenteric side (Figure 1). The Gastrografin contrast study revealed a Y-shaped structure formed by the sigmoid colon and the duplicated colonic segment (Figure 2).

Further diagnostic work-up

Colonoscopy showed bifurcation of the colonic lumen at the sigmoid colon and the duplicated segment was filled with huge fecalomas (Figure 3).

Operative findings

Figure 1 Abdomino-pelvic computed tomography showed a blind, dilated bowel loop filled with fecal material, directed to right upper quadrant of abdomen. A: Axial view; B: Coronal view.

Figure 2 Gastrografin colon study revealed a Y-shaped structure formed by the sigmoid colon and duplicated colonic segment.

We established a diagnosis of sigmoid colon duplication based on these findings and decided to perform a laparoscopic examination. An approximately 30-cm-long, tubular bowel segment originating in the mesenteric side of the sigmoid colon was identified(Figure 4). This bowel segment was located under the mesocolon. It extended to the RUQ of the abdomen and ended near the duodenum. The surgery was converted to open surgery due to adhesion. Segmental resection of the sigmoid colon with duplication was performed.

Pathologic findings

Grossly, the duplicated segment, measuring 34 cm in length, was connected to the native sigmoid colon on the mesenteric side (Figure 5). Microscopically, the duplicated segment revealed all three layers of the bowel wall with scattered heterotopic tissue(Figure 6). Heterotopic tissue composed of fetal glomeruli and scattered tubules was detected under higher magnification, with immunoreactivity against vimentin, CK7,and PAX8. A diagnosis of EIRT associated with colonic duplication was made(Figure 7).

FINAL DIAGNOSIS

The final diagnosis was sigmoid colon duplication with benign EIRT.

Figure 3 Colonoscopy images. A: Bifurcation of the colonic lumen; B: The duplicated segment was filled with huge fecalomas.

Figure 4 During the laparoscopic examinatin, an about 30 cm long, tubular bowel segment originating from the mesenteric side of the sigmoid colon was identified. SC: Sigmoid colon; DS: Duplication segment.

TREATMENT

Segmental resection of the sigmoid colon with duplication was performed.

OUTCOME AND FOLLOW-UP

The postoperative period was uneventful and the patient was discharged nine days after the surgery without complications. She has been doing well and was satisfied with the outcome 12 mo after the follow-up.

DISCUSSION

Alimentary tract duplication is a very rare congenital malformation that occurs most commonly in the small bowel[3]. Colonic duplications account for only 6%-7% of all duplications, with the cecum the most common site[4]. Various theories have been proposed, but the etiology of colonic duplication has not been established. This anomaly is often diagnosed in childhood, but some may go undiagnosed until adulthood[5-7]. A combination of abdominal pain and intestinal obstruction symptoms is the most common clinical manifestation of colonic duplications. Patients with colonic duplication are often accompanied by vertebral and genitourinary anomalies[3,8]. However, the patient in this case report did not have any other anomalies except colonic duplication.

Figure 5 Grossly, the duplicated segment, measuring 34 cm in length, was connected to the native sigmoid colon at the mesenteric side.

Figure 6 Microscopically, the duplication segment shows all 3 layers of bowel wall with scatted heterotopic tissue (Hematoxylin and eosin stain, ×12.5).

A preoperative diagnosis of colonic duplication is often difficult[1,4]. General imaging modalities, such as plain abdominal radiography or ultrasonography, provide limited information. The diagnosis is best established with CT imaging or contrast enema.Although a large diverticulum may appear similar to tubular type colonic duplication,haustral marking on contrast enema may suggest duplication, as in this case.

Figure 7 The heterotopic tissue is consistent with ectopic immature renal tissue. A: Higher magnifications view (Hematoxylin and eosin stain, × 200);B: Immunohistochemical staining (× 200) for vimentin; C: Immunohistochemical staining (× 200) for CK7; D: Immunohistochemical staining (× 200) for PAX8.

Colonic duplication characteristically arises from the mesenteric border of the colon and may have direct communication[1]. It has multiple bowel wall layers, including a smooth muscle coat and an epithelial mucosal lining. There have been reports of many types of heterotopic tissue identified within the duplications[1,3]. The common types of ectopic tissue include gastric mucosal, squamous, and pancreatic tissue. Rarely,malignant change can occur in a colonic duplication[9]. EIRT was found in the wall of the duplication in this case. EIRT is a metanephric remnant arrested in an extra-renal site due to a migratory defect and rarely can give rise to extra-renal Wilms tumors[2].EIRT was composed of fetal glomeruli and scattered tubules. EIRT is rarely reported and most cases are associated with teratoma. There has been report of the presence of EIRT within the wall of a colonic duplication in an 8-mo-old male child[2], and this is the first report of EIRT found in the colonic duplication in an adult, to our knowledge.Whenever EITR is found, a proper histological interpretation is mandatory for a differential diagnosis between benign EIRT and a true Wilms tumor[2,10]. Because this case was not associated with teratoma and did not show any malignant features such as cellular atypia or nuclear pleomorphism, we plan to follow-up without further treatment. Surgical resection is the treatment of choice for symptomatic and asymptomatic colonic duplications to prevent complications and a tendency for malignant degeneration[1,4]. Because duplications always share blood supply with the native colon and malignant changes can occur in the conjunction area, the extent of resection should include the duplication and a short segment of normal colon[3].

CONCLUSION

Many types of heterotopic tissue and tumor were identified within the wall of colon duplication. EIRT was found in the wall of the duplication in this case. Treatment plan is modified based on histological findings. Therefore, a comprehensive histopathologic examination for ectopic tissues or tumors is mandatory after resection of colon duplication.