Endoscopic removal of foreign bodies:A retrospective study in Japan

Kenji JL Limpias Kamiya,Naoki Hosoe,Kaoru Takabayashi,Yukie Hayashi,Xi Sun,Ryoichi Miyanaga,Kayoko Fukuhara,Seiichiro Fukuhara,Makoto Naganuma,Atsushi Nakayama,Motohiko Kato,Tadateru Maehata,Rieko Nakamura,Koichi Ueno,Junichi Sasaki,Yuko Kitagawa,Naohisa Yahagi,Haruhiko Ogata,Takanori Kanai

Kenji JL Limpias Kamiya,Yukie Hayashi,Ryoichi Miyanaga,Makoto Naganuma,Takanori Kanai,Division of Gastroenterology and Hepatology,Department of Internal Medicine,Keio University School of Medicine,Tokyo 160-8582,Japan

Naoki Hosoe,Kaoru Takabayashi,Xi Sun,Kayoko Fukuhara,Seiichiro Fukuhara,Haruhiko Ogata,Center for Diagnostic and Therapeutic Endoscopy,Keio University School of Medicine,Tokyo 160-8582,Japan

Xi Sun,Department of Gastroenterology and Hepatology,Chinese PLA General Hospital,Beijing 100853,China

Atsushi Nakayama,Motohiko Kato,Tadateru Maehata,Naohisa Yahagi,Division of Research and Development for Minimally Invasive Treatment,Cancer Center,Keio University School of Medicine,Tokyo 160-8582,Japan

Rieko Nakamura,Yuko Kitagawa,Department of Surgery,Keio University School of Medicine,Tokyo 160-8582,Japan

Koichi Ueno,Junichi Sasaki,Department of Emergency and Critical Care Medicine,Keio University School of Medicine,Tokyo 160-8582,Japan

Abstract

Key words:Anisakis parasite;Endoscopic removal;Food bolus impaction;Foreign body;Grasping forceps

INTRODUCTION

The ingestion of foreign bodies (FBs) and food bolus impaction (FBI) are common problems in clinical practice globally.Pre-endoscopic series have shown that ≥ 80% of FBs are likely to pass without requiring intervention,10%-20% will require nonoperative intervention,and ≤ 1% will require surgery.The ingestion of FBs mainly occurs in the pediatric population,with a peak incidence between 6 mo and 6 years of age.Among adults,it occurs more commonly in those with psychiatric disorders,alcohol intoxication,and mental retardation and in incarcerated individuals looking for another opportunity to be sent to a medical facility.Edentulous adults are also at risk of the ingestion of FBs,including their own dental prostheses (DP),and FBI.Since the first report in 1972 on the removal of a FB using a flexible endoscope by McKechnie,this method has continued to evolve owing to its advantages,such as surgery avoidance,reduced cost,accessible technical facilities,visualization improvement,reduced morbidity,and high removal success rate (＞ 95%)as well as the possibility of diagnosis of other diseases.However,to the best of our knowledge,currently,there are no reports on the endoscopic management of FBs and FBIs in Japan.

MATERIALS AND METHODS

Study design

The present observational study was conducted at the Center for Diagnostic and Therapeutic Endoscopy of Keio University Hospital and was approved by the ethics committee of Keio University Hospital (approval ID 20180281).The study included the data of patients with a history of FB ingestion or FBI who underwent endoscopic therapy at Keio University Hospital between November 2007 and August 2018.Data were collected from medical records,and endoscopic details were collected through an endoscopic reporting system (Solemio ENDO,Olympus,Tokyo,Japan).Only procedures performed with a flexible gastrointestinal endoscope were considered.Additionally,only patients who underwent a technique involving FBs or FBI removal from the digestive tract were included.Patients who underwent a technique involving pushing of the FBI into the stomach without posterior removal were excluded.The following data were extracted:(1) Sex;(2) Age;(3) Outpatient or inpatient;(4) FB type;(5) FB location (laryngopharynx,esophagus,stomach,small intestine,or colon);(6) FB type according to anatomical location;(7) Procedure time;(8) Procedure type[esophagogastroduodenoscopy (EGD),colonoscopy (CS),or single-balloon enteroscopy (SBE)];(9) Extraction device type;(10) Most used devices according to FB type;and (11) Success and technical complications.According to age,patients were divided into the following four groups:Children (＜ 15 years old),youth and adults(15-59 years old),old adults (60-79 years old),and very old adults (＞ 79 years old).FBs that were not very frequent were categorized as “others” (catheters,toothpicks,coins,cotton swabs,packs of illegal drugs,feces,shells,staples,stents,and vinyl).Procedure time was considered as the time required for removal of the FBs or FBI,which was calculated from the insertion of the flexible endoscope to complete extraction of the FB or FBI,including resolution of complications.With regard to the extraction device,we considered all devices used for the removal of the FB or FBI and for the protection of the digestive tract,including devices that were used in combination.Technical complications were considered as complications involving deep laceration,perforation,or bleeding of the mucosa that required additional procedures to achieve hemostasis.In this study,we did not take into account lacerations that showed slight bleeding,in which hemostasis occurred naturally.Procedure success was considered as complete removal of the FB or FBI from the digestive tract,with subsequent confirmation of absence of the FB or FBI on assessment of the digestive tract.

Statistical analysis

Categorical data are expressed as number and percentage (%),and the procedure duration was calculated as mean with standard deviation (SD) expressed in minutes.All statistical analyses were performed using IBM SPSS software,version 24.0 (IBM Corp.,Armonk,NY,United States).

RESULTS

Patient background

A total of 215 procedures were performed between November 2007 and August 2018.Patient background data are presented in Table1.Of the 215 procedures,106 (49.3%)were performed in male patients and 109 (50.7%) were performed in female patients.With regard to age,2 (1%) procedures were performed in children,77 (36%) were performed in youth and adults,109 (51%) were performed in old adults,and 27 (12%)were performed in very old adults.Additionally,180 (83.7%) procedures were performed in outpatients and 35 (16.3%) in inpatients.

Foreign body type and location

Data on FB type are presented in Table2.In this study,the most common FB was press-trough-pack (PTP) medications [72 (33.5%) cases],followed by FBI [47 (21.9%)cases],Anisakis parasite (AP) [41 (19.1%) cases],DP [23 (10.7%) cases],fish bone [9(4.2%) cases],endoscopic video capsule device (VCE) [7 (3.3%) cases],spoon [3 (1.4%)cases],and others [13 (6.0%) cases].On the other hand,the most common location was the esophagus [130 (60.5%) cases],followed by the stomach [68 (31.6%) cases],small intestine [8 (3.7%) cases],laryngopharynx [5 (2.3%) cases],and colon [4 (1.9%) cases].

Table1 Patient background

Anatomical location,most common foreign body type,and procedure time

Data on FB type according to anatomical location are presented in Table3.The most common FBs according to anatomical location were PTP medications (40%) and DP(40%) in the laryngopharynx,PTP medications (48.5%) and FBI (36.2%) in the esophagus,AP (57.4%) and DP (13.2%) in the stomach,DP (37.5%) and VCE (25%) in the small intestine,and VCE (75%) in the colon.

Procedure type and time

As shown in Table4,procedure type was dependent on the FB location.The most commonly used procedure was EGD [207 (96.3%) cases],followed by SBE [5 (2.3%)cases] and CS [3 (1.4%) cases].The procedure times for FB and FBI removal according to location were as follows:Laryngopharynx,14.2 min (SD 2.7 min);esophagus,14.5 min (SD 1.1 min);stomach,14.7 min (SD 1.3 min);small intestine,31.1 min (SD 1.0 min);and colon,45.2 min (SD 2.7 min).There was no significant difference in the procedure time across the locations.

Most used devices according to FB type

Data on the most used devices according to FB type are presented in Table5.Different types of devices were used.Devices were used in combination or were used alone.The most common devices according to FB type were a large caliber soft oblique cap with grasping forceps for PTP medications (83.3%) (Figure1 and Video,grasping forceps for FBI (76.5%),biopsy forceps for AP (97.5%),a large caliber soft oblique cap with grasping forceps for DP (73.9%),a large caliber soft oblique cap with grasping forceps for fish bone (88.8%),a net retriever for VCE (85.7%),and an over-tube with a snare for spoon (66.6%).

Success and technical complications

FB removal was successful in all 215 cases (100%),and a complication was noted in only 1 case (0.5%).The complication involved a deep laceration of the mucosa that occurred during DP extraction,and the bleeding was immediately stopped with hemostasis endoclips.There was no need for surgery or re-admission after hospital discharge.

DISCUSSION

In the present study,most patients were older adults,and this might be because the index of older adults is the highest in the entire Japanese population at present.PTP medications was the most common FB,as it is commonly used in Japan for packaging of medications and is ingested mostly among older adults owing to the use of medications for their different pathologies.Sugawaindicated in a review that PTP medications can be removed using a snare net with a protector over-tube or a retractable latex-rubber condom-type hood for mucosal protection.In our study,83.3% of cases of impaction of PTP medications underwent removal involving a large caliber soft oblique cap and grasping forceps to avoid any damage to the mucosa,and there was no complication in any of the cases.As shown in Figure1 and Video,a large caliber soft oblique cap can store the PTP medications avoiding mucosal damage,and thus,no complication occurred.A change in the material of PTP medications should Number of patients (%)be considered to avoid impaction and complications associated with PTP medications ingestion,as it was the most common FB in this study.

Table2 Foreign body type and retrieved location

FBI was the second most common type of FB (21.9% of cases),and it was noted in the esophagus,which was the anatomical location with the highest incidence in this study.The endoscopic treatment options according to the American Society for Gastrointestinal Endoscopy (ASGE) include in block removal using grasping devices,a piecemeal approach,and advancement of the food bolus into the stomach.Some controversy is present regarding the push technique as there is a perforation risk when applying this technique without first examining the distal esophagus.However,two large studies did not report perforation in a total of 375 patients using the push technique.Their approach involved the application of gentle pressure to the center of the food bolus or the reduction of the bolus by piecemeal removal followed by the application of gentle pressure when advancement of the bolus was not successful.It is considered safe to perform dilation after bolus extraction when there is an esophageal stricture in order to avoid recurrence.According to previous studies,the push technique is considered as the primary method with a success rate of over 90% and with minimal complications.The most commonly used technique in our endoscopic center was the piecemeal approach with grasping forceps (76.5% of cases),and there was no complication during or after the extraction.In patients with a suspected etiology of eosinophilic esophagitis,biopsy samples were taken after removal of the FBI,and in patients who presented with an esophageal stricture,balloon dilatation was performed in order to avoid recurrences.The third most common FB in this study was AP (19.1%),and it was commonly located in the stomach.This high percentage might be associated with the fact that in Japan,there is a cultural tradition of eating raw fish in popular dishes,such as sushi and sashimi,which are the main sources of nematodes.According to Tokiwa,of the 301 cases of food poisoning in Japan between 2013 and 2015,294 cases involved Anisakis food poisoning,and the most common source of infection was mackerel fish.Opportunities to eat raw fish in sushi bars and Japanese restaurants outside Japan are increasing;therefore,it is important to know about the existence of this parasite and its endoscopic management,as removal is the only approach for symptom relief.In our study,97.5% of all cases of AP underwent extraction using biopsy forceps,and this approach was successful in all cases without any complications.The fourth most common FB in this study was DP.This FB was common in our study owing to the fact that people using a DP are often old adults or very old adults.The European Society of Gastrointestinal Endoscopy (ESGE),the ASGE,and Bertonirecommend the use of an over-tube as it helps to protect the esophageal and laryngeal mucosa from lacerations.If this protective device is not available,the use of a transparent cap or latex rubber hood is recommended to prevent mucosal injury.In a recent study,Zhangrecommended the use of a transparent cap to allow a short procedure time and a clear visual field,in addition to mucosal protection.We used a largecaliber soft oblique cap in 73.9% of cases.The only complication noted in this study was for DP despite the fact that grip and protection devices for the esophageal mucosa were used.This complication might have been associated with the extended time taken to visit our hospital,which increased the risk of a complication,the fact that the extraction was performed by a beginner endoscopist as our center is a university hospital,the limited working space in the esophagus,or the fact that the rate of complications for sharp-pointed objects is as high as 35%.There were also cases of fish bone impaction and VCE retention,but they were not very frequent.In cases involving fish bone,which is a sharp-pointed object,according to the ASGE and ESGE guidelines and other reports,we performed extraction using a large caliber soft oblique cap and grasping forceps in 88.8% of cases,and there were no complications.On the other hand,in the few cases of VCE retention in the small intestine,we successfully used SBE,without any complications.However,doubleballoon enteroscopy is also recommended by few reportsThere were also some cases of VCE retention in the colon,and the device was removed by conventional CS using a net retriever in almost all cases.This approach was successful in all cases,and there were no complications.

Table3 Common foreign bodies at each anatomical location

The ASGE and ESGE have stated that only 10%-20% of FB ingestion cases require endoscopic removal;however,according to our study,we believe that this percentage might be higher in Japan owing to differences in dietary habits,average population age,and cultural backgrounds between people from Western countries and those from Asian countries,and the most common FBs were sharp-pointed objects that have a higher risk of complications when compared with other types of FBs.Webbreported a success rate of 98.8% for endoscopic removal,Lireported a success rate of 94.1% in China,and Zhangreported a success rate of 96.1% in South China,and most complications involved sharp-pointed objects,similar to our only complication;however,our success rate was 100%.

The present study has some limitations.The study involved a retrospective analysis with a small sample size.There might have been several biases in the current study,such as selection bias associated with the patient enrollment methodology (use of an endoscopic database only).Thus,patients who were expected to have difficulty in endoscopic removal might have directly undergone surgery.Nevertheless,to our knowledge,this is the first study to elucidate the efficacy and safety of endoscopic retrieval of FBs and FBI in Japan.

In conclusion,endoscopic management of FBs is extremely safe and effective.The devices used for FB extraction depend on the location and type of FB.As most FBs in our study were sharp-pointed objects,we suggest always placing a large caliber soft oblique cap on the tip of the endoscope and not a straight transparent cap (Figure1),this will help avoid mucosal injury from the sharp edges during extraction and will provide a clear visual field.

Table4 Procedure type and time

Table5 Foreign bodies and devices most used for extraction

Figure1 Difference between a large-caliber,soft oblique cap and straight,conventional-caliber transparent cap.A:A large-caliber,soft oblique cap can store the press-through-pack (PTP),protecting the digestive mucosa when retrieving the PTP;B:A straight,conventional-caliber transparent cap cannot cover the sharp edges,which may result in mucosal injury.

ARTICLE HIGHLIGHTS

Research background

Endoscopic extraction of foreign bodies (FBs) is a method that can present complications depending on the type of management performed.

Research motivation

To date,there are no studies evaluating the endoscopic management of FBs in Japan.

Research objectives

The aim of this study is to elucidate level of safety and efficacy in the endoscopic management of FBs and food boluses in Japan.

Research methods

This study was a retrospective medical record analysis.A total of 215 procedures were performed at Keio University Hospital between November 2007 and August 2018.Data were collected from medical charts,and endoscopic details were collected from an endoscopic reporting system.Procedures performed with a flexible gastrointestinal endoscope were only taken into account.Patients who underwent a technique involving FB or food bolus removal from the digestive tract were only included.Data on patient sex,patient age,outpatient,inpatient,FB type,FB location,procedure time,procedure type,removal device type,success,and technical complications were reviewed and analyzed retrospectively.

Research results

The most common type of FB were press-through-pack (PTP) [72 (33.5%) cases],food bolus [47(21.9%)],Anisakis parasite (AP) [41 (19.1%) cases].Most FBs were located in the esophagus [130(60.5%) cases] followed by the stomach [68 (31.6%) cases].The most common FBs according to anatomical location were PTP (40%) and dental prostheses (DP) (40%) in the laryngopharynx,PTP (48.5%) in the esophagus,AP (57.4%) in the stomach,DP (37.5%) in the small intestine and video capsule endoscopy device (75%) in the colon.A transparent cap with grasping forceps was the most commonly used device [82 (38.1%) cases].The success rate of the procedure was 100%,and complication was observed in only one case (0.5%).

Research conclusions

Endoscopic management of FBs is extremely safe and effective.The devices used for FB extraction depend on the location and type of FB.

Research perspectives

We suggest always placing a large caliber soft oblique cap on the tip of the endoscope and not a straight transparent cap,this will help avoid mucosal injury from the sharp edges during extraction and will provide a clear visual field.