耳穴及生活方式預防2型糖尿病的隨機對照試驗研究

陳琳　張伯宇

摘要?目的：探討耳穴及生活方式對2型糖尿病前期人群的預防效果。方法：選取2017年5月至2018年3月在順義區中醫院接受體檢的2型糖尿病前期人群92例進行觀察，按照隨機數表法分為對照組和觀察組，每組46例，對照組給予常規干預，觀察組在對照組的基礎上給予耳穴壓豆干預治療。比較2組2型糖尿病前期人群干預前后的糖化血紅蛋白（HbA1c）、體質量指數（BMI）、空腹血糖（FPG）、餐后2 h血糖（P2 hPG）、收縮壓（SBP）、舒張壓（DBP）、總膽固醇（TC）、三酰甘油（TG）、高密度脂蛋白（HDL）及低密度脂蛋白（LDL）變化情況，以及干預1年后糖尿病轉歸情況。結果：與干預前比較，對照組僅FPG與P2 hPG較干預前均顯著降低，觀察組FPG、P2 hPG、TC、HDL及HbA1c較干預前顯著降低，而LDL顯著升高，差異均有統計學意義（P<0.05）;干預后2組比較，觀察組FPG、P2 hPG、TC、LDL及HbA1c降低更顯著，而LDL升高更顯著，差異有統計學意義（P<0.05）;干預后觀察組糖尿病轉化率2.17%（1/46），對照組糖尿病轉化率13.04%（6/46），差異有統計學意義（P<0.05）。結論：耳穴壓豆聯合生活方式干預可更有效地改善2型糖尿病期人群的血糖及血脂水平，有效降低。

關鍵詞?耳穴;生活方式;干預;2型糖尿病;前期人群;血糖;血脂;糖尿病轉化率;干預

Auricular Acupuncture and Lifestyle Prevention of Type 2 Diabetes：A Randomized Controlled Trial

Chen Lin，Zhang Boyu

（Department of Infectious Diseases，Beijing Hospital of Traditional Chinese Medicine in Shunyi District，Beijing 101300，China）

Abstract?Objective：To study the prevention outcomes of auricular acupuncture and lifestyle in treating Type 2 Diabetes. Methods：A total of 92 patients with prediabetes type 2 during physical examination in Beijing Hospital of Traditional Chinese Medicine in Shunyi District from May 2017 to March 2018 were selected. According to the random number table method，patients were divided into the control group and the observation group，with 46 cases each. The control group was received routine intervention. Additionally the observation group was treated with auricular point pressure bean. The changes of HbA1c，BMI，FPG，P2 hPG，SBP，DBP，TC，TG，HDL，and LDL before and after intervention in type 2 diabetics were compared between the 2 groups. The outcomes were also contracted after 1 year of intervention. Results：Groups were compared before and after intervention. FPG and P2 hPG of the control group were significantly lower than before. FPG，P2 hPG，TC，HDL，and HbA1c of the observation group were significantly lower than before the intervention，while LDL was significantly higher. There was statistical difference in the groups（P<0.05）; After intervention FPG，P2 hPG，TC，LDL，and HbA1c decreased more significantly in the observation group，while LDL increased significantly（P<0.05）; a total of 2.17% patients of the observation group converted to diabetes mellitus after intervention（1/46）. The control group converted to diabetes at the rate of 13.04%（6/46）. The differences between the groups were significant（P<0.05）. Conclusion：Auricular acupuncture combined with lifestyle intervention can improve blood glucose and lipid levels in type 2 diabetics more effectively than routine intervention，and effectively reduce the conversion rate of diabetes.

Key Words?Auricular acupressure; Lifestyle intervention; Prediabetes type 2; Blood glucose; Lipid levels; Diabetes conversion rate; Intervene; Significant; Improve

中圖分類號：R242;R587.1文獻標識碼：Adoi：10.3969/j.issn.1673-7202.2019.03.047

隨著人們生活方式的改變及人口老齡化，2型糖尿病已經成為全球性的公共衛生問題。目前糖尿病患病率在全球呈急劇增加的趨勢，從1980年的1.53億人增長到2008年的3.47億人[1]。2型糖尿病通過生活方式的干預在很大程度上是可以預防的，且具有遠期療效[2-3]。但僅通過生活方式的干預來預防糖尿病是困難的。……