青光安顆粒對青光眼濾過術后濾過泡瘢痕化的抑制作用

喻娟　彭俊　顏家朝

摘要?目的：探討青光安顆粒對青光眼濾過術后濾過泡瘢痕化的抑制作用。方法：選取2016年4月至2018年9月湖南中醫藥大學第一附屬醫院收治的行濾過性手術治療后濾過泡瘢痕化患者76例作為研究對象，按照隨機數字表法隨機分為對照組和觀察組，每組38例。2組均采用常規小梁切除濾過性手術，對照組術后給予血栓通膠囊，觀察組術后給予青光安顆粒，2組均連續治療2個月。比較2組治療成功率、手術前后不同時間患眼最佳矯正視力（BCVA）及眼壓，記錄2組術后并發癥發生情況。結果：2組患者術后7 d患眼術區均形成功能性濾過泡，觀察組治療成功率明顯高于對照組（P<0.05）。與術前比較，術后1、2個月2組患眼BCVA及濾過泡高度均明顯提高/增加（P<0.05），且觀察組明顯高于對照組（P<0.05）;2組患眼眼壓均明顯降低（P<0.05），且觀察組明顯低于對照組（P<0.05）。2組總并發癥發生率差異無統計學意義（P>0.05）。結論：青光眼濾過術后給予青光安顆?？筛黠@地提高患眼BCVA，降低眼壓，有效抑制濾過泡瘢痕化。

關鍵詞?青光安顆粒;青光眼濾過術;濾過泡瘢痕化;抑制作用

Inhibitory Effects of Qingguang′an Granule on Filtering Bleb Scar After Glaucoma Filtration

Yu Juan，Peng Jun，Yan Jiachao

（Department of Ophthalmology，The First Hospital of Hunan University of Chinese Medicine，Changsha 410007，China）

Abstract?Objective：To investigate the inhibitory effects of Qingguang′an Granule on filtering bleb scar after glaucoma filtration. Methods：A total of 76 patients with filtering bleb scar after glaucoma filtration in the First Hospital of Hunan University of Chinese Medicine from April 2016 to September 2018 were selected and divided into the observation group and the control group according to the random number table method，with 38 cases in each group. The 2 groups were treated with conventional trabeculectomy and filtration. The control group was given Xueshuantong Capsule after operation，while the observation group was given Qingguang′an Granules. The 2 groups were treated continuously for 2 months. The success rate of the 2 groups，the best corrected visual acuity（BCVA）and intraocular pressure at different times before and after operation were compared. The postoperative complications of the 2 groups were recorded. Results：Functional blebs were formed in the eyes of the 2 groups at 7 days after operation. The treatment success rate of the observation group was significantly higher than that of the control group（P<0.05）. Compared with preoperative situation，the BCVA and filtering bleb height significantly increased in the 2 groups at 1 and 2 months after operation. The observation group was significantly higher than that of the control group（P<0.05）. The intraocular pressure significantly decreased，of which the experiment group was significantly lower than that of the control group（P<0.05）. There was no significant difference in the incidence of total complications between the 2 groups（P>0.05）. Conclusion：The application of Qingguang′an Granules after glaucoma filtration can significantly increase BCVA，reduce intraocular pressure as well as effectively inhibit bleb scarring.

Key Words?Qingguang′an Granule; Glaucoma filtration; Filtering bleb scar; Inhibitory effects

中圖分類號：R276文獻標識碼：Adoi：10.3969/j.issn.1673-7202.2019.03.031

青光眼是最主要的致盲眼病之一，眼壓升高、視功能損害是其主要特征。青光眼濾過性手術仍是治療青光眼的主要治療方式，其主要目的是建立永久性的通道將房水引流到球結膜下，通過形成濾過泡，降低眼壓[1]。但術后纖維組織增生、瘢痕粘連嚴重導致濾過泡瘢痕化，是青光眼濾過術失敗的主要原因之一[2-3]。……