復方甘草酸苷注射液與前列地爾聯合治療急性黃疸型肝炎的臨床效果研究

李妍

[摘要] 目的 探討復方甘草酸苷注射液聯合前列地爾治療急性黃疸型肝炎的效果。 方法 收集的76例患者均為2014年3月～2015年10月來我院治療的黃疸型肝炎病例，隨機分為兩組，每組各38例，對照組用門冬氨酸鉀鎂注射液與苦黃注射液治療，觀察組使用復方甘草酸苷注射液與前列地爾聯合治療，1個療程為4周。比較分析兩組的臨床療效及治療前后TBIL、AST、ALT水平。 結果 觀察組治療后的總有效率為92.11%，顯著高于對照組的73.68%，差異有統計學意義（P<0.05）。兩組治療后組內比較：對照組和觀察組TBIL、AST、ALT與治療前比較明顯降低，差異有統計學意義（P<0.05）。兩組治療后組間比較：觀察組TBIL、AST、ALT明顯低于對照組，差異有統計學意義（P<0.05）。 結論 復方甘草酸苷注射液與前列地爾聯合治療急性黃疸型肝炎效果較好，可提高臨床治療總有效率，緩解臨床癥狀，改善肝功能，值得臨床推廣應用。

[關鍵詞] 急性黃疸型肝炎；復方甘草酸苷；前列地爾；靜脈滴注

[中圖分類號] R512 [文獻標識碼] B [文章編號] 1673-9701（2017）13-0102-03

[Abstract] Objective To discuss the effect of compound glycyrrhizin injection combined with alprostadil in treatment of acute icteric hepatitis. Methods 76 patients with icteric hepatitis treated in our hospital from March 2014 to October 2015 were selected and randomly divided into two groups， each with 38 cases. Patients in the control group were given potassium magnesium aspartate injection and Kuhuang injection， while patients in the observation group were treated by compound glycyrrhizin injection combined with alprostadil， both for a treatment course of 4 weeks. The clinical effects and TBIL， AST， and ALT levels before and after treatment were compared between two groups. Results The overall response rate of the observation group was 92.11%， significantly higher than the 73.68% in the control group， the difference was significant（P<0.05）. As to intragroup comparison， after treatment， the TBIL， AST， and ALT levels were significantly lower than those before treatment in both groups， the difference was significant（P<0.05）. As to intergroup comparison， the TBIL， AST， and ALT levels in the observation group after treatment were significantly lower than in the control group， the difference was significant（P<0.05）. Conclusion Compound glycyrrhizin injection combined with alprostadil have good effect in treatment of acute icteric hepatitis， which can improve the overall response rate， relieve clinical symptoms， and improve liver function， thus is worthy to be promoted.

[Key words] Acute icteric hepatitis； Compound glycyrrhizin； Alprostadil； Intravenous drip

急性肝炎是臨床常見疾病之一，按照急性肝炎患者是否有黃疸表現及血清膽紅素升高情況可將其分為急性黃疸型肝炎、急性無黃疸型肝炎[1]。急性黃疸型肝炎是臨床常見的一種傳染性疾病，患者多以倦怠、食欲減退、皮膚黃染、上腹部不適、肝區有壓痛和叩擊痛等為主要臨床表現，同時伴有各種轉氨酶、膽紅素等生化指標升高，對我國居民健康造成嚴重危害，采用及時有效的方法對急性黃疸型肝炎患者進行干預，大部分患者可預后良好，在短期內徹底治愈，否則可進展為慢性肝炎、肝硬化，甚至肝癌，嚴重威脅到患者的生命安全[2-3]。本院對2014年3月～2015年10月收集的38例黃疸型肝炎患者使用復方甘草酸苷注射液與前列地爾聯合治療，效果較為滿意，現報道如下。

1 資料與方法

1.1 一般資料

共收集76例患者，均為2014年3月～2015年10月來我院治療的急性黃疸型肝炎患者，納入標準：符合《病毒性肝炎防治方案》的診斷標準[4]。……