泛昔洛韋聯合生殖器皰疹皰液自體接種治療生殖器皰疹的臨床療效分析

（1. 贛州市腫瘤醫院藥劑科 江西 341000；2. 贛州市贛縣計劃生育服務站 江西 341100）

摘 要 目的：探討泛昔洛韋聯合生殖器皰疹皰液自體接種治療生殖器皰疹的臨床療效。方法：將我院收治的86例生殖器皰疹患者隨機分為試驗組和對照組，對試驗組患者給予泛昔洛韋聯合生殖器皰疹皰液自體接種治療，對對照組患者僅給予泛昔洛韋治療，比較兩治療組患者的臨床療效、至臨床癥狀改善的時間和不良反應的發生情況。結果：試驗組患者的治愈率為83.72%、總有效率為100.00%，均顯著高于對照組（分別為39.53%和93.02%，P均<0.05）；試驗組患者的復發率為16.28%，顯著低于對照組的60.47%（P<0.05）；試驗組患者的至皮損愈合平均時間、自覺疼痛和瘙癢平均持續時間也均顯著短于對照組（P均<0.05）。試驗組中有2例患者發生輕度的乏力和發熱，但這些不良反應均在2 d內自行消失；對照組中未見明顯不良反應發生。結論：泛昔洛韋聯合生殖器皰疹皰液自體接種治療能夠顯著提高生殖器皰疹的治療效果、降低復發率，具有臨床應用價值。

關鍵詞 生殖器皰疹 泛昔洛韋 生殖器皰疹皰液自體接種

中圖分類號：R752.11； R459.9 文獻標識碼：B 文章編號：1006-1533（2014）17-0023-03

Analysis of clinical efficacy of famciclovir combined with

genital herpes blister fluid auto-inoculation in the treatment of genital herpes*

WEN Bing1，2**

（1. Department of Pharmacy， The Tumor Hospital of Ganzhou City， Jiangxi 341000， China；

2. Ganxian’s Family Planning Service Station of Ganzhou City， Jiangxi， 341100， China）

Abstract Objective： To explore the clinical efficacy of the autologous vaccination of genital herpes blister fluid in the treatment of genital herpes. Methods： Eighty-six cases of patients with genital herpes were randomly divided into an experimental group and a control group， in which famciclovir combined with the autologous vaccination of genital herpes blister fluid were given in the experimental group while only famciclovir in the control group. Clinical efficacy， time for the appearance of the improvement of clinical symptoms and incidence of adverse reaction were compared between two groups. Results： The rates of the cure and the total effectiveness were 83.72% and 100% in the experimental group， which were significantly higher than those in the control group （39.53% and 93.02%， P<0.05）； the recurrence rate was 16.28% in the experiment group， which was significantly lower than that in the control group （60.47%， P<0.05）； the average times for the healing of skin damage and the conscious pain and itching were significantly shorter in the experiment group than in the control group （P<0.05）. Two cases of mild weakness and fever occurred in the experimental group， which could disappear within two days， however， such adverse reactions could not be observed in the control group. Conclusion： Famciclovir combined with the autologous vaccination of genital herpes blister fluid can significantly improve the treatment effect of genital herpes， reduce the recurrence rate and possesses a value of clinical application.

Key words genital herpes； famciclovir； genital herpes blister fluid autologous vaccination

生殖器皰疹是臨床上常見的性傳播疾病之一，主要由人單純皰疹病毒-2（herpes simplex virus-2， HSV-2）感染引起，患者在臨床上主要表現為生殖器炎性病變，癥狀具有多樣性和反復性，可引發生殖器癌變，但目前尚無根治生殖器皰疹的特效藥物[1-2]。我院應用泛昔洛韋聯合生殖器皰疹皰液自體接種治療生殖器皰疹取得了很好的臨床效果，現報告如下。……