【摘 要】 目的探析在甲狀腺疾病的診治中血清促甲狀腺激素受體抗體(TRab)放免檢測的應用價值。方法收集我院2012年9月至2013年9月收治的甲狀腺疾病患者180例和正常對照組60例作為研究對象,將甲狀腺疾病患者按照疾病種類分為橋本氏病組、Graves組和其他甲狀腺疾病組,應用RRA以及CLLA。分別對四組患者進行血清TRab放免檢測、游離甲狀腺素檢測(FT4)、游離三碘甲狀腺原氨酸檢測(FT3)和TRab陽性率檢測。結果Graves組的血清TRab水平(85.2±30.5)和TRab陽性率[91.95%(80/87)]顯著高于對照組的(5.4±0.9,P<0.05)和[0%(0/0),P<0.05];橋本氏病組的TRab陽性率[21.15%(11/52)]顯著高于對照組的[0%(0/0),P<0.05],但是其血清TRab水平(5.8±1.4)則稍高于對照組(5.4±0.9),其差異無統計學意義(P>0.05)。結論血清TRab放免檢測在甲狀腺疾病尤其是橋本氏病和Graves病的診治中,具有相當的診斷價值。
【關鍵詞】 血清TRab放免檢測;甲狀腺疾病;Graves病;橋本氏病
【中圖分類號】 R581【文獻標識碼】 BDiagnosis and Treatment of Thyroid Disease Detected by Radioimmunoassay of Serum TRAb Value
Wang Dazhong
(Ya'an wing the county hospital laboratory,Si Chuan,625000)【Abstract】 ObjectiveAnalysis of diagnosis and treatment of thyroid diseases in serum thyrotrophic receptor antibody (TRab) put the value of free detection.MethodsIn our hospital from September 2012 to September 2013 were treated 180 cases of thyroid disease patients and normal control group of 60 patients for the study,patients were divided into categories by disease thyroid disease Hashimoto's disease group,Graves groups and other thyroid disease group,and CLLA RRA.Were applied to the four groups of patients serum TRab RIA detection,detection of free thyroxin (FT4),free triiodothyronine three detection (FT3) and TRab positive rate.ResultsSerum levels of Graves TRab group (85.2±30.5) and TRab positive rate [91.95% (80/87)] was significantly higher than (5.4±0.9,P<0.05),and [0%(0/0),P<0.05];TRab positive rate of Hashimoto's disease group [21.15%(11/52)] was significantly higher than [0%(0/0),P<0.05],but the serum TRab level (5.8±1.4) is slightly higher (5.4±0.9),the difference was not statistically significant (P> 0.05).ConclusionSerum TRab radioimmunoassay in the diagnosis and treatment of thyroid diseases,especially Hashimoto's disease and Graves'disease, and has considerable diagnostic value.
【Keywords】 Serum TRab radioimmunoassay;Thyroid disease;Graves's disease;Hashimoto's disease甲狀腺疾病目前在臨床上發現的一般包括甲狀腺功能減退病、橋本氏病、甲狀腺炎、甲狀腺腫瘤、甲狀腺癌和毒性彌漫性甲狀腺腫伴甲亢(Graves病)等,其中以Graves病、橋本氏病最為常見。促甲狀腺激素受體抗體(TRab)是人機體內的一種特異性免疫蛋白,他在甲狀腺疾病尤其是Graves病的發生、發展和治療中起到了不可忽視的作用。本次研究對180例甲狀腺患者和60例健康人群進行血清TRab放免檢測等,旨在探析其在甲狀腺疾病診治中的應用價值,現報道如下。
1資料與方法
1.1一般資料收集我院2012年9月至2013年9月收治的甲狀腺疾病患者180例和正常對照組60例作為研究對象,其中男100例,女140例;年齡16-69歲,平均年齡(38.4±13.6)歲。……