Lipofuscin-and Melanin-related Fundus Autofluorescence in Patients with Submacular Idiopathic Choroidal Neovascularization

Xijia Peng， Wenfang Zhang

1 Department of Ophthalmology， Rehabilitation Center Hospital of Gansu， Lanzhou 730000， China

2 Department of Ophthalmology， the Second Hospital of Lanzhou University， Lanzhou 730030， China

Methods

Patients

FAF，NIA，FFA and ICGA examination

Results

Figure 1 The fellow eye of a 26-year-old female with ICNV shows normal FAF （A）and NIA （B）．

Figure 2 A 39-year-old male with ICNV．A： Early phase FFA reveals a juxtafoveal classic CNV；B：Early phase ICGA confirms a well-defined CNVM with a narrow dark rim； C：FAF shows hypoautofluorescence at the site of CNV．Around the CNV， the distribution of autofluorescence is normal．Note the hypoautofluorescent areas adjacent to CNV caused by subretinal hemorrhage；D：NIA show hypoautofluorescence at the site of CNV．A well-defined hyperautofluorescent ring around the CNV is present．

Discussion

Figure 3 A 26-year-old female with ICNV．A：Early phase FFA reveals a juxtafoveal classic CNV．B：Early phase ICGA confirms a well-defined CNVM with a dark rim；C，D：FAF and NIA show hypoautofluorescence at the site of CNV．A well-defined hyperautofluorescent ring is seen surrounding the CNV in both FAF and NIA images．

Figure 4 A 34-year-old male with ICNV．A： Early phase FFA reveals a juxtafoveal classic CNV； B： Early phase ICGA confirms a well-defined CNVM．A distinct dark rim around the CNV is present；C，D：FAF and NIA images exhibit hypoautofluorescence at the site of CNV．An ill-defined hyperautofluorescent ring is observed in FAF image（C）， while a well-defined hyperautofluorescent ring is observed surrounding the CNV in NIA image （D）．