靜滴阿昔洛韋黃芪治療扁平疣療效觀察

何漢欽 仇俊鵬 鄧新華

[摘要] 目的 評估靜滴阿昔洛韋黃芪治療扁平疣的臨床療效。方法 應用聯合靜滴阿昔洛韋黃芪注射液治療36例(治療組)扁平疣療效與36例只靜滴阿昔洛韋(對照組)作比較,療程2周。結果治療組治愈31例,治療組痊愈率為86.2%,未見不良反應;對照組治愈24例,對照組痊愈率為67%。χ2=3.97,P<0.05,治療組明顯優于對照組。結論靜滴阿昔洛韋黃芪治療扁平疣療效好,安全,值得在臨床中試用。

[關鍵詞] 扁平疣;阿昔洛韋;黃芪

[中圖分類號] R752.5+2 [文獻標識碼] A[文章編號] 1004-8650(2009)06-107-02

The Clinical Effect of Acyclovir and Mongolian Milkvetch Root on Verruca Plana Juvenilis

HE Han-qing1,QIU Jun-peng1,DENG Xin-hua2

[Abstract] Objective In order to observe the clinical effect of acyclovir and Mongolian milkvetch root in the treatment of patient with verruca plana juvenilis. Methods 36 patients with verruca plana juvenilis were instiled with acyclovir and Mongolian milkvetch (therapeutic group),and 36 patients with verruca plana juvenilis were instiled with acyclovir only (control group),all for two weeks. Results The recovery rate oftherapeutic group(86.2%) was higher than the recovery rate ofcontrol group(67%). There was a statistically significant difference between two groups﹙χ2=3.97,P<0.05=.Conclusion Instilling acyclovir and Mongolian milkvetch root is a effective method in the treatment of patient with verruca plana juvenilis.

[Key words] verruca plana juvenilis; acyclovir; mongolian milkvetch root

1996年6月-2002年6月,我科應用靜滴阿昔洛韋(麗珠集團麗珠制藥廠)聯合黃芪注射液(天津神威制藥股份有限公司)治療扁平疣36例,與單獨靜滴阿昔洛韋治療扁平疣36例作對照,結果顯示阿昔洛韋聯合黃芪注射液治療扁平疣可明顯提高療效,副作用少,現報告如下。

1臨床資料

1.1一般資料

72例扁平疣患者均來自我院皮膚專科門診患者,具有典型的臨床癥狀和體征。均符合扁平疣的診斷標準[1],隨機分成治療組和對照組。治療組男17例,女19例,年齡為6-43歲;中位年齡25.4歲,病程為2-36月,平均為4個月。對照組,男15例,女21例,年齡為7-41歲;中位年齡26歲,病程為7周-48個月,平均為5.6個月。皮損多數發生于面部,少數發于背,手,頸部,亦有以上兩個部位同時發病或泛發的。

所有病例均在2周內未服用或外用抗病毒藥。在2個月內均未使用免疫增效劑或免疫抑制劑。妊娠,哺乳期婦女,嚴重肝、腎功能不全,阿昔洛韋,黃芪注射液過敏者均不作為實驗對象。

1.2治療方法

治療組以0.9%N.S250ml阿昔洛韋500mg,靜滴每日一次,[兒童阿昔洛韋用量按5mg/(kg·d)計算]。同時,聯合5%G.N.S250ml+黃芪注射液20ml靜滴,每天一次[兒童黃芪用量按0.5mg/(kg·d)計算]。……